Description
| 抗体名: | CBFA2T2 Antibody (PACO44570) |
| 抗体コード: | PACO44570 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB, IHC |
| 推奨される希釈: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
| 反応性: | Human |
| 免疫原: | Recombinant Human Protein CBFA2T2 protein (325-604AA) |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 精製方法: | Antigen Affinity Purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: CBFA2T2 antibody at 1.82µg/ml + 293T whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 68, 64, 29, 66 kDa. Observed band size: 68 kDa.. |
 | Immunohistochemistry of paraffin-embedded human testis tissue using PACO44570 at dilution of 1:100. |
| バックグラウンド: | Transcriptional corepressor which facilitates transcriptional repression via its association with DNA-binding transcription factors and recruitment of other corepressors and histone-modifying enzymes. Can repress the expression of MMP7 in a ZBTB33-dependent manner. May function as a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 which is produced in acute myeloid leukemia with the chromosomal translocation t(8;21). May thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region. |
| シノニム: | Protein CBFA2T2 (ETO homologous on chromosome 20) (MTG8-like protein) (MTG8-related protein 1) (Myeloid translocation-related protein 1) (p85), CBFA2T2, EHT MTGR1 |
| UniProt Protein Function: | CBFA2T2: May function as a complex with the chimeric protein RUNX1/AML1-CBFA2T1/MTG8 which is produced in acute myeloid leukemia with the chromosomal translocation t(8;21). May thus be involved in the repression of AML1-dependent transcription and the induction of G-CSF/CSF3-dependent cell growth. May be a tumor suppressor gene candidate involved in myeloid tumors with the deletion of the 20q11 region. Belongs to the CBFA2T family. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Transcription, coactivator/corepressor Chromosomal Location of Human Ortholog: 20q11 Cellular Component: nucleus Molecular Function:protein binding; metal ion binding; transcription corepressor activity; transcription factor activity Biological Process: epithelial cell differentiation; positive regulation of transcription from RNA polymerase II promoter; negative regulation of transcription, DNA-dependent |
| NCBI Summary: | In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 (AML1) gene fused to the 3'-region of the CBFA2T1 (MTG8) gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene binds to the AML1-MTG8 complex and may be important in promoting leukemogenesis. Several transcript variants are thought to exist for this gene, but the full-length natures of only three have been described. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O43439 |
| NCBI GenInfo Identifier: | 34395613 |
| NCBI Gene ID: | 9139 |
| NCBI Accession: | O43439.1 |
| UniProt Secondary Accession: | O43439,Q5TGE4, Q5TGE5, Q5TGE6, Q5TGE7, Q8IWF3, Q96B06 Q96L00, Q9H436, Q9UJP8, B2RAE6, F8W6D7, |
| UniProt Related Accession: | O43439 |
| Molecular Weight: | 604 |
| NCBI Full Name: | Protein CBFA2T2 |
| NCBI Synonym Full Names: | core-binding factor, runt domain, alpha subunit 2; translocated to, 2 |
| NCBI Official Symbol: | CBFA2T2 |
| NCBI Official Synonym Symbols: | EHT; p85; MTGR1; ZMYND3 |
| NCBI Protein Information: | protein CBFA2T2; MTG8-like protein; MTG8-related protein 1; ETO homolog on chromosome 20; ETO homologous on chromosome 20; myeloid translocation-related protein 1; myeloid translocation gene-related protein 1 |
| UniProt Protein Name: | Protein CBFA2T2 |
| UniProt Synonym Protein Names: | ETO homologous on chromosome 20; MTG8-like protein; MTG8-related protein 1; Myeloid translocation-related protein 1; p85 |
| Protein Family: | Protein |
| UniProt Gene Name: | CBFA2T2 |
| UniProt Entry Name: | MTG8R_HUMAN |
