| UniProt Protein Function: | CASP8AP2: Participates in TNF-alpha-induced blockade of glucocorticoid receptor (GR) transactivation at the nuclear receptor coactivator level, upstream and independently of NF- kappa-B. Suppresses both NCOA2- and NCOA3-induced enhancement of GR transactivation. Involved in TNF-alpha-induced activation of NF-kappa-B via a TRAF2-dependent pathway. Acts as a downstream mediator for CASP8-induced activation of NF-kappa-B. Required for the activation of CASP8 in FAS-mediated apoptosis. Required for histone gene transcription and progression through S phase. |
| UniProt Protein Details: | Protein type:Apoptosis; Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 6q15 Cellular Component: PML body; mitochondrion; cytoplasm; nucleus Molecular Function:protein binding; DNA binding; SUMO polymer binding; death receptor binding; apoptotic protease activator activity; caspase activator activity; transcription corepressor activity Biological Process: caspase activation; regulation of transcription, DNA-dependent; induction of apoptosis via death domain receptors; transcription, DNA-dependent; signal transduction; cell cycle |
| NCBI Summary: | This protein is highly similar to FLASH, a mouse apoptotic protein identified by its interaction with the death-effector domain (DED) of caspase 8. Studies of FLASH protein suggested that this protein may be a component of the death-inducing signaling complex that includes Fas receptor, Fas-binding adapter FADD, and caspase 8, and plays a regulatory role in Fas-mediated apoptosis. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, Nov 2008] |
| UniProt Code: | Q9UKL3 |
| NCBI GenInfo Identifier: | 5533376 |
| NCBI Gene ID: | 9994 |
| NCBI Accession: | AF165161 |
| UniProt Secondary Accession: | Q9UKL3,Q6PH76, Q7LCQ7, Q86YD9, Q9NUQ4, Q9NZV9, Q9P2N1 Q9Y563, A2RUB7, E1P553, |
| UniProt Related Accession: | Q9UKL3 |
| Molecular Weight: | 222,658 Da |
| NCBI Full Name: | Homo sapiens FLASH mRNA, partial cds |
| NCBI Synonym Full Names: | caspase 8 associated protein 2 |
| NCBI Official Symbol: | CASP8AP2 |
| NCBI Official Synonym Symbols: | CED-4; FLASH; RIP25 |
| NCBI Protein Information: | CASP8-associated protein 2 |
| UniProt Protein Name: | CASP8-associated protein 2 |
| UniProt Synonym Protein Names: | FLICE-associated huge protein |
| UniProt Gene Name: | CASP8AP2 |
| UniProt Entry Name: | C8AP2_HUMAN |
