Description
| 抗体名: | CAPN1 Antibody (PACO08168) |
| 抗体コード: | PACO08168 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB |
| 推奨される希釈: | |
| 反応性: | Human, Mouse, Rat |
| 免疫原: | Human CAPN1 |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| 精製方法: | Antigen Affinity Purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
| シノニム: | calpain 1, (mu/I) large subunit;CAPN1;CANP;CANP1;CANPL1;muCANP;muCL ; |
| UniProt Protein Function: | CAPN1: Calcium-regulated non-lysosomal thiol-protease which catalyze limited proteolysis of substrates involved in cytoskeletal remodeling and signal transduction. Forms a heterodimer with a small (regulatory) subunit (CAPNS1). Ubiquitous. Activated by micromolar concentrations of calcium and inhibited by calpastatin. Belongs to the peptidase C2 family. |
| UniProt Protein Details: | Protein type:EC 3.4.22.52; Protease; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 11q13 Cellular Component: focal adhesion; membrane; cytoplasm; plasma membrane; cytosol Molecular Function:protein binding; calcium-dependent cysteine-type endopeptidase activity; calcium ion binding Biological Process: extracellular matrix disassembly; extracellular matrix organization and biogenesis; receptor catabolic process; positive regulation of cell proliferation; proteolysis |
| NCBI Summary: | The calpains, calcium-activated neutral proteases, are nonlysosomal, intracellular cysteine proteases. The mammalian calpains include ubiquitous, stomach-specific, and muscle-specific proteins. The ubiquitous enzymes consist of heterodimers with distinct large, catalytic subunits associated with a common small, regulatory subunit. This gene encodes the large subunit of the ubiquitous enzyme, calpain 1. Several transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Nov 2010] |
| UniProt Code: | P07384 |
| NCBI GenInfo Identifier: | 115574 |
| NCBI Gene ID: | 823 |
| NCBI Accession: | P07384.1 |
| UniProt Secondary Accession: | P07384,Q2TTR0, Q6DHV4, |
| UniProt Related Accession: | P07384 |
| Molecular Weight: | |
| NCBI Full Name: | Calpain-1 catalytic subunit |
| NCBI Synonym Full Names: | calpain 1, (mu/I) large subunit |
| NCBI Official Symbol: | CAPN1 |
| NCBI Official Synonym Symbols: | CANP; muCL; CANP1; CANPL1; muCANP |
| NCBI Protein Information: | calpain-1 catalytic subunit; CANP 1; calpain mu-type; micromolar-calpain; calpain-1 large subunit; calpain, large polypeptide L1; calcium-activated neutral proteinase 1; cell proliferation-inducing protein 30; cell proliferation-inducing gene 30 protein |
| UniProt Protein Name: | Calpain-1 catalytic subunit |
| UniProt Synonym Protein Names: | Calcium-activated neutral proteinase 1; CANP 1; Calpain mu-type; Calpain-1 large subunit; Cell proliferation-inducing gene 30 protein; Micromolar-calpain; muCANP |
| Protein Family: | Calpain |
| UniProt Gene Name: | CAPN1 |
| UniProt Entry Name: | CAN1_HUMAN |
