Description
| Product Name: | Canine UMOD Recombinant Protein |
| Product Code: | RPPB2511 |
| Size: | 10µg |
| Species: | Canine |
| Target: | UMOD |
| Synonyms: | Tamm-Horsfall urinary glycoprotein, THP, FJHN, HNFJ, THGP, MCKD2, ADMCKD2, UMOD, Uromodulin. |
| Source: | Canine Urine |
| Physical Appearance: | Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | The UMOD protein was lyophilized from 0.4�m filtered solution at a concentration of 0.1mg/ml containing deionized water. |
| Solubility: | Add deionized water to prepare a working stock solution of approximately 0.5mg/mL and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture. |
| Stability: | Lyophilized UMOD although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution UMOD should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Amino Acid Sequence: | RSCSECHSNA TCMEDGMVTT CSCLVGFTGS GFECVDLDEC AIPGAHNCSE GSSCMNTLGS YLCTCPDGFR LTPGLGCIDV DECSEPGLSR CHALATCINN KGNYSCVCPA GYRGDGQHCE CSPGSCGPGL DCVPVGDALV CADPCQEHRI LDEYWRSTEY GAGYTCDVGL NGWYRFTGPG GVRLAETCVP VLHCNTAAPM WLNGTHPTRD QGIVNRTACA HWRGHCCLWD ASIQVKACAG GYYVYNLTET PECYLAYCTD PTSVLGTCEE CSVEEDCKSH DGMWSCQCKQ DFNVTDLFLL DRLECRPNDI KVSLSKCQLK SLGFEKVFMY LRDSQCSGFN ERGDRDWVSV VTPARDGPCG TVMVRNETHA TYSNTLYLAD EIVIRDRNIK INFECSYPLD MKVSLETSLQ PIVSSLNISV GGTGMFTVRM ALFQTPDYTQ PYQGSSVTLT TEAFLYVGTM LDGGDLSRFA LLMTNCYATP SSNATDPLKY FIIQDRCPRT TDSTIQVVEN GESPQGRFSV QMFRFAGNYD LVYLHCEVYL CDIINEKCKP TCSGTRFRSG GIIDQSRVLN LGPITRKNVQ AVVSRAASS |
Uromodulin is the most abundant protein in normal urine. Its secretion in urine follows proteolytic cleavage of the ectodomain of its glycosyl phosphatidylinosital-anchored counterpart that is situated on the luminal cell surface of the loop of Henle. Uromodulin plays a role as a constitutive inhibitor of calcium crystallization in renal fluids. Secretion of uromodulin in urine provides protection against urinary tract infections caused by uropathogenic bacteria. Defects in Uromodulin expression are associated with the autosomal dominant renal disorders medullary cystic kidney disease-2 (MCKD2) and familial juvenile hyperuricemic nephropathy (FJHN). These disorders are characterized by juvenile onset of hyperuricemia, gout, and progressive renal failure. While several transcript variants may exist for this gene, the full-length natures of only two have been described to date. UMOD is involved in regulating the circulating activity of cytokines as it binds to il-1, il-2 and tnf with high affinity.
UMOD is an 85-kDa glycoprotein which is produced in the thick ascending limb of Henle�s loop and early distal convoluted tubules of the nephron.
| UniProt Protein Function: | Uromodulin: Functions in biogenesis and organization of the apical membrane of epithelial cells of the thick ascending limb of Henle's loop (TALH), where it promotes formation of complex filamentous gel-like structure that may play a role in the water barrier permeability. May serve as a receptor for binding and endocytosis of cytokines (IL-1, IL-2) and TNF. Facilitates neutrophil migration across renal epithelia. |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q862Z3 |
| NCBI GenInfo Identifier: | 62901365 |
| NCBI Gene ID: | 403510 |
| NCBI Accession: | Q862Z3.1 |
| UniProt Secondary Accession: | Q862Z3 |
| UniProt Related Accession: | Q862Z3 |
| Molecular Weight: | 70,178 Da |
| NCBI Full Name: | Uromodulin |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | UMOD�� |
| NCBI Official Synonym Symbols: | THP�� |
| NCBI Protein Information: | uromodulin |
| UniProt Protein Name: | Uromodulin |
| UniProt Synonym Protein Names: | Tamm-Horsfall urinary glycoprotein; THP |
| Protein Family: | Uromodulin |
| UniProt Gene Name: | UMOD�� |
| UniProt Entry Name: |
