Description
| Product Name: | Canine IL6 Recombinant Protein |
| Product Code: | RPPB0533 |
| Size: | 10µg |
| Species: | Canine |
| Target: | IL6 |
| Synonyms: | IL6, IL-6, Interleukin-6. |
| Source: | Sf9 Insect cells |
| Physical Appearance: | Sterile Filtered colorless solution. |
| Formulation: | IL6 protein solution (0.5mg/ml) contains Phosphate Buffered Saline (pH 7.4) and 10% glycerol. |
| Stability: | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. |
| Purity: | Greater than 95.0% as determined by SDS-PAGE. |
| Amino Acid Sequence: | FPTPGPLAGD SKDDATSNSL PLTSANKVEE LIKYILGKIS ALRKEMCDKF NKCEDSKEAL AENNLHLPKL EGKDGCFQSG FNQETCLTRI TTGLVEFQLH LNILQNNYEG DKENVKSVHM STKILVQMLK SKVKNQDEVT TPDPTTDASL QAILQSQDEC VKHTTIHLIL RSLEDFLQFS LRAVRIMLEH HHHHH |
Il-6 is a cytokine with a wide variety of biological functions: it plays an essential role in the final differentiation of b-cells into ig-secreting cells, it induces myeloma and plasmacytoma growth, it induces nerve cells differentiation, in hepatocytes it induces acute phase reactants.
IL6 Canine Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 195 amino acids (21-207a.a.) and having a molecular mass of 22.0kDa (Molecular size on SDS-PAGE will appear at approximately 18-28kDa).IL6 is expressed with an 8 amino acid His-tag at C-Terminus and purified by proprietary chromatographic techniques.
| UniProt Protein Function: | Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasmacytoma growth and induces nerve cells differentiation. |
| UniProt Code: | P41323 |
| NCBI GenInfo Identifier: | 729836 |
| NCBI Gene ID: | 403985 |
| NCBI Accession: | P41323.1 |
| UniProt Related Accession: | P41323 |
| Molecular Weight: | Predicted Molecular Mass: 24.9kDaAccurate Molecular Mass: 25kDa |
| NCBI Full Name: | Interleukin-6 |
| NCBI Synonym Full Names: | interleukin 6 |
| NCBI Official Symbol: | IL6�� |
| NCBI Official Synonym Symbols: | IL-6�� |
| NCBI Protein Information: | interleukin-6 |
| UniProt Protein Name: | Interleukin-6 |
| Protein Family: | Interleukin |
| UniProt Gene Name: | IL6�� |
