| UniProt Protein Function: | CADM3: Involved in the cell-cell adhesion. Has both calcium- independent homophilic cell-cell adhesion activity and calcium- independent heterophilic cell-cell adhesion activity with IGSF4, PVRL1 and PVRL3. Interaction with EPB41L1 may regulate structure or function of cell-cell junctions. Belongs to the nectin family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Cell adhesion; Membrane protein, integral Chromosomal Location of Human Ortholog: 1q21.2-q22 Cellular Component: cell-cell adherens junction; integral to plasma membrane; intercellular junction; plasma membrane Molecular Function:cell adhesion molecule binding; protein homodimerization activity; receptor activity; receptor binding Biological Process: cell recognition; heterophilic cell adhesion; homophilic cell adhesion; intercellular junction assembly and maintenance; protein localization |
| NCBI Summary: | IGSF4B is a brain-specific protein related to the calcium-independent cell-cell adhesion molecules known as nectins (see PVRL3; MIM 607147) (Kakunaga et al., 2005 [PubMed 15741237]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q8N126 |
| NCBI GenInfo Identifier: | 74759761 |
| NCBI Gene ID: | 57863 |
| NCBI Accession: | Q8N126.1 |
| UniProt Secondary Accession: | Q8N126,Q8IZQ9, Q9NVJ5, Q9UJP1, |
| UniProt Related Accession: | Q8N126 |
| Molecular Weight: | 38,326 Da |
| NCBI Full Name: | Cell adhesion molecule 3 |
| NCBI Synonym Full Names: | cell adhesion molecule 3 |
| NCBI Official Symbol: | CADM3 |
| NCBI Official Synonym Symbols: | BIgR; NECL1; TSLL1; IGSF4B; Necl-1; synCAM3 |
| NCBI Protein Information: | cell adhesion molecule 3 |
| UniProt Protein Name: | Cell adhesion molecule 3 |
| UniProt Synonym Protein Names: | Brain immunoglobulin receptor; Immunoglobulin superfamily member 4B; IgSF4B; Nectin-like protein 1; NECL-1; Synaptic cell adhesion molecule 3; SynCAM3; TSLC1-like protein 1; TSLL1 |
| Protein Family: | Cell adhesion molecule |
| UniProt Gene Name: | CADM3 |
| UniProt Entry Name: | CADM3_HUMAN |
