| NCBI Summary: | The protein encoded by this gene is the pore-forming subunit of an N-type voltage-dependent calcium channel, which controls neurotransmitter release from neurons. The encoded protein forms a complex with alpha-2, beta, and delta subunits to form the high-voltage activated channel. This channel is sensitive to omega-conotoxin-GVIA and omega-agatoxin-IIIA but insensitive to dihydropyridines. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011] |
| UniProt Code: | Q00975 |
| NCBI GenInfo Identifier: | 4502523 |
| NCBI Gene ID: | 774 |
| NCBI Accession: | NP_000709 |
| UniProt Related Accession: | Q00975 |
| Molecular Weight: | Predicted Molecular Mass: 25.1kDaAccurate Molecular Mass: 28kDa |
| NCBI Full Name: | voltage-dependent N-type calcium channel subunit alpha-1B isoform 1 |
| NCBI Synonym Full Names: | calcium voltage-gated channel subunit alpha1 B |
| NCBI Official Symbol: | CACNA1B |
| NCBI Official Synonym Symbols: | BIII; CACNN; DYT23; Cav2.2; NEDNEH; CACNL1A5 |
| NCBI Protein Information: | voltage-dependent N-type calcium channel subunit alpha-1B |
| UniProt Protein Name: | Voltage-dependent N-type calcium channel subunit alpha-1B |
| UniProt Synonym Protein Names: | Brain calcium channel III; BIII; Calcium channel, L type, alpha-1 polypeptide isoform 5; Voltage-gated calcium channel subunit alpha Cav2.2 |
| Protein Family: | GTP-binding protein |
| UniProt Gene Name: | CACNA1B |
| UniProt Entry Name: | CAC1B_HUMAN |
