Description
| 抗体名: | C1D Antibody, HRP conjugated (PACO31689) |
| 抗体コード: | PACO31689 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA |
| 推奨される希釈: | |
| 反応性: | Human |
| 免疫原: | Recombinant Human Nuclear nucleic acid, binding protein C1D protein (1-135AA) |
| 憲法: | Liquid |
| ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| 精製方法: | >95%, Protein G purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | HRP |
| バックグラウンド: | Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB. |
| シノニム: | Nuclear nucleic acid, binding protein C1D (hC1D), C1D |
| UniProt Protein Function: | C1D: Plays a role in the recruitment of the RNA exosome complex to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA; this function may include MPHOSPH6. Can activate PRKDC not only in the presence of linear DNA but also in the presence of supercoiled DNA. Can induce apoptosis in a p53/TP53 dependent manner. May regulate the TRAX/TSN complex formation. Potentiates transcriptional repression by NR1D1 and THRB. Belongs to the C1D family. |
| UniProt Protein Details: | Protein type:Nucleolus; DNA-binding; Transcription, coactivator/corepressor; Nuclear receptor co-regulator Chromosomal Location of Human Ortholog: 2p13-p12 Cellular Component: transcriptional repressor complex; cytoplasm; nucleolus; nucleus; nuclear exosome (RNase complex) Molecular Function:ligand-dependent nuclear receptor binding; protein binding; DNA binding; RNA binding; transcription corepressor activity Biological Process: maturation of 5.8S rRNA; transcription, DNA-dependent; apoptosis; negative regulation of transcription, DNA-dependent |
| NCBI Summary: | The protein encoded by this gene is a DNA binding and apoptosis-inducing protein and is localized in the nucleus. It is also a Rac3-interacting protein which acts as a corepressor for the thyroid hormone receptor. This protein is thought to regulate TRAX/Translin complex formation. Alternate splicing results in multiple transcript variants that encode the same protein. Multiple pseudogenes of this gene are found on chromosome 10.[provided by RefSeq, Jun 2010] |
| UniProt Code: | Q13901 |
| NCBI GenInfo Identifier: | 74754472 |
| NCBI Gene ID: | 10438 |
| NCBI Accession: | Q13901.1 |
| UniProt Secondary Accession: | Q13901,Q05D64, A8K336, D6W5F8, |
| UniProt Related Accession: | Q13901 |
| Molecular Weight: | 141 |
| NCBI Full Name: | Nuclear nucleic acid-binding protein C1D |
| NCBI Synonym Full Names: | C1D nuclear receptor corepressor |
| NCBI Official Symbol: | C1D |
| NCBI Official Synonym Symbols: | LRP1; hC1D; Rrp47; SUNCOR; SUN-CoR |
| NCBI Protein Information: | nuclear nucleic acid-binding protein C1D; C1D DNA-binding protein; nuclear DNA-binding protein; C1D nuclear receptor co-repressor; small unique nuclear receptor corepressor; small unique nuclear receptor co-repressor |
| UniProt Protein Name: | Nuclear nucleic acid-binding protein C1D |
| Protein Family: | Nuclear nucleic acid-binding protein |
| UniProt Gene Name: | C1D |
| UniProt Entry Name: | C1D_HUMAN |
