Description
| 抗体名: | BPGM Antibody (PACO44860) |
| 抗体コード: | PACO44860 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB, IHC |
| 推奨される希釈: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
| 反応性: | Human |
| 免疫原: | Recombinant Human Bisphosphoglycerate mutase protein (1-259AA) |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 精製方法: | Antigen Affinity Purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: BPGM antibody at 2.87µg/ml + Human placenta tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 30 kDa. Observed band size: 30 kDa.. |
 | Immunohistochemistry of paraffin-embedded human placenta tissue using PACO44860 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human ovarian cancer using PACO44860 at dilution of 1:100. |
| バックグラウンド: | Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3-bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.1) and phosphatase (EC 3.1.3.13) activities. |
| シノニム: | Bisphosphoglycerate mutase (BPGM) (EC 5.4.2.4) (2,3-bisphosphoglycerate mutase, erythrocyte) (2,3-bisphosphoglycerate synthase) (EC 5.4.2.11) (2,3-diphosphoglycerate mutase) (DPGM) (BPG-dependent PGAM), BPGM |
| UniProt Protein Function: | BPGM: Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of its allosteric effector 2,3- bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.1) and phosphatase (EC 3.1.3.13) activities. Defects in BPGM are the cause of bisphosphoglycerate mutase deficiency (BPGMD). A disease characterized by hemolytic anemia, splenomegaly, cholelithiasis and cholecystitis. Belongs to the phosphoglycerate mutase family. BPG- dependent PGAM subfamily. |
| UniProt Protein Details: | Protein type:EC 5.4.2.4; EC 3.1.3.13; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Phosphatase (non-protein); EC 5.4.2.11; Isomerase Chromosomal Location of Human Ortholog: 7q33 Molecular Function:phosphoglycerate mutase activity; bisphosphoglycerate mutase activity; bisphosphoglycerate phosphatase activity Biological Process: erythrocyte development; glycolysis; dephosphorylation; carbohydrate metabolic process; respiratory gaseous exchange Disease: Bisphosphoglycerate Mutase Deficiency |
| NCBI Summary: | 2,3-diphosphoglycerate (2,3-DPG) is a small molecule found at high concentrations in red blood cells where it binds to and decreases the oxygen affinity of hemoglobin. This gene encodes a multifunctional enzyme that catalyzes 2,3-DPG synthesis via its synthetase activity, and 2,3-DPG degradation via its phosphatase activity. The enzyme also has phosphoglycerate phosphomutase activity. Deficiency of this enzyme increases the affinity of cells for oxygen. Mutations in this gene result in hemolytic anemia. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2009] |
| UniProt Code: | P07738 |
| NCBI GenInfo Identifier: | 130350 |
| NCBI Gene ID: | 669 |
| NCBI Accession: | P07738.2 |
| UniProt Related Accession: | P07738 |
| Molecular Weight: | 30kDa |
| NCBI Full Name: | Bisphosphoglycerate mutase |
| NCBI Synonym Full Names: | bisphosphoglycerate mutase |
| NCBI Official Symbol: | BPGM |
| NCBI Official Synonym Symbols: | DPGM; ECYT8 |
| NCBI Protein Information: | bisphosphoglycerate mutase |
| UniProt Protein Name: | Bisphosphoglycerate mutase |
| UniProt Synonym Protein Names: | 2,3-bisphosphoglycerate mutase, erythrocyte; 2,3-bisphosphoglycerate synthase (EC:3.1.3.13, EC:5.4.2.11); 2,3-diphosphoglycerate mutase; DPGM; BPG-dependent PGAM |
| Protein Family: | Bisphosphoglycerate mutase |
| UniProt Gene Name: | BPGM |
| UniProt Entry Name: | PMGE_HUMAN |
