| UniProt Protein Function: | BOLL: Probable RNA-binding protein, which may be required during spermatogenesis. May act by binding to the 3'-UTR of mRNAs and regulating their translation. Belongs to the RRM DAZ family. 4 isoforms of the human protein are produced by alternative splicing.Protein type: TranslationChromosomal Location of Human Ortholog: 2q33Cellular Component: cytoplasmMolecular Function: protein binding; translation activator activity; RNA binding; nucleotide bindingBiological Process: positive regulation of translational initiation; meiosis; multicellular organismal development; spermatogenesis; cell differentiation |
| UniProt Protein Details: | |
| NCBI Summary: | This gene belongs to the DAZ gene family required for germ cell development. It encodes an RNA-binding protein which is more similar to Drosophila Boule than to human proteins encoded by genes DAZ (deleted in azoospermia) or DAZL (deleted in azoospermia-like). Loss of this gene function results in the absence of sperm in semen (azoospermia). Histological studies demonstrated that the primary defect is at the meiotic G2/M transition. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q8N9W6 |
| NCBI GenInfo Identifier: | 14719414 |
| NCBI Gene ID: | 66037 |
| NCBI Accession: | NP_149019.1 |
| UniProt Secondary Accession: | Q8N9W6,Q0JW32, Q53T62, Q969U3, B4DZA4 |
| UniProt Related Accession: | Q8N9W6 |
| Molecular Weight: | 31301 |
| NCBI Full Name: | protein boule-like isoform 2 |
| NCBI Synonym Full Names: | boule-like RNA-binding protein |
| NCBI Official Symbol: | BOLL |
| NCBI Official Synonym Symbols: | BOULE |
| NCBI Protein Information: | protein boule-like |
| UniProt Protein Name: | Protein boule-like |
| UniProt Synonym Protein Names: | |
| Protein Family: | Protein boule |
| UniProt Gene Name: | BOLL |
| UniProt Entry Name: | BOLL_HUMAN |
