Description
| 抗体名: | BMF Antibody (PACO08025) |
| 抗体コード: | PACO08025 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB |
| 推奨される希釈: | |
| 反応性: | Human |
| 免疫原: | Human Bmf |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.1% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| 精製方法: | Protein G Purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
| シノニム: | BCL2 modifying factor;Bmf;AW260063;AW411872 ; |
| UniProt Protein Function: | BMF: May play a role in apoptosis. Isoform 1 seems to be the main initiator. Interacts with MCL1, BCL2, BCL2L1/BCL-Xl, BCL2A1 and BCL2L2/BCL-w. Interacts with the myosin V actin motor complex through its binding to DLC2. Isoform 1 is mainly expressed in B-lymphoid cells. Isoform 2 and isoform 3 are mainly expressed in B-CLL and normal B-cells. Belongs to the Bcl-2 family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Apoptosis; Cytoskeletal Chromosomal Location of Human Ortholog: 15q14 Cellular Component: mitochondrial outer membrane; plasma membrane; acrosome; cytosol; myosin complex Molecular Function:protein binding Biological Process: positive regulation of protein homooligomerization; apoptosis; anoikis |
| NCBI Summary: | The protein encoded by this gene belongs to the BCL2 protein family. BCL2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein contains a single BCL2 homology domain 3 (BH3), and has been shown to bind BCL2 proteins and function as an apoptotic activator. This protein is found to be sequestered to myosin V motors by its association with dynein light chain 2, which may be important for sensing intracellular damage and triggering apoptosis. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q96LC9 |
| NCBI GenInfo Identifier: | 56748563 |
| NCBI Gene ID: | 90427 |
| NCBI Accession: | Q96LC9.1 |
| UniProt Secondary Accession: | Q96LC9,Q2M396, Q6NT30, Q6NT56, Q6P9F6, Q7Z7D4, Q7Z7D5 Q9H7K7, |
| UniProt Related Accession: | Q96LC9 |
| Molecular Weight: | 184 |
| NCBI Full Name: | Bcl-2-modifying factor |
| NCBI Synonym Full Names: | Bcl2 modifying factor |
| NCBI Official Symbol: | BMF |
| NCBI Protein Information: | bcl-2-modifying factor |
| UniProt Protein Name: | Bcl-2-modifying factor |
| Protein Family: | Bcl-2-modifying factor |
| UniProt Gene Name: | BMF |
| UniProt Entry Name: | BMF_HUMAN |
