Description
| 抗体名: | ATP6AP1 Antibody (PACO07441) |
| 抗体コード: | PACO07441 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB |
| 推奨される希釈: | ELISA:1:10000-1:20000, WB:1:500-1:2000 |
| 反応性: | Human, Mouse, Rat |
| 免疫原: | Synthesized peptide derived from human V-ATPase S1. at AA range: 421-470 |
| 憲法: | Liquid |
| ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| 精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Western Blot analysis of 1,mouse-lung 2,mouse-brain 3,mouse-spleen 4,mouse-kidney cells using primary antibody diluted at 1:500(4°C overnight). Secondary antibody:Goat Anti-rabbit IgG IRDye 800( diluted at 1:5000, 25°C, 1 hour). |
| シノニム: | V-type proton ATPase subunit S1 (V-ATPase subunit S1) (Protein XAP-3) (V-ATPase Ac45 subunit) (V-ATPase S1 accessory protein) (Vacuolar proton pump subunit S1) |
| UniProt Protein Function: | ATP6AP1: Vacuolar ATPase is responsible for acidifying a variety of intracellular compartments in eukaryotic cells. Belongs to the vacuolar ATPase subunit S1 family. |
| UniProt Protein Details: | Protein type:Transporter; EC 3.6.3.14; Energy Metabolism - oxidative phosphorylation; Hydrolase; Membrane protein, integral Chromosomal Location of Human Ortholog: Xq28 Cellular Component: vacuolar membrane; integral to membrane; endosome membrane; proton-transporting two-sector ATPase complex Molecular Function:transporter activity; hydrogen ion transporting ATP synthase activity, rotational mechanism; hydrogen ion transporting ATPase activity, rotational mechanism; Rab GTPase binding; ATP binding Biological Process: positive regulation of osteoblast differentiation; proton transport; cellular iron ion homeostasis; ATP hydrolysis coupled proton transport; pH reduction; insulin receptor signaling pathway; positive regulation of bone resorption; transferrin transport; transmembrane transport; establishment of organelle localization; positive regulation of exocytosis |
| NCBI Summary: | This gene encodes a component of a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. Vacuolar ATPase (V-ATPase) is comprised of a cytosolic V1 (site of the ATP catalytic site) and a transmembrane V0 domain. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, and receptor-mediated endocytosis. The encoded protein of this gene may assist in the V-ATPase-mediated acidification of neuroendocrine secretory granules. This protein may also play a role in early development. [provided by RefSeq, Aug 2013] |
| UniProt Code: | Q15904 |
| NCBI GenInfo Identifier: | 12230759 |
| NCBI Gene ID: | 537 |
| NCBI Accession: | Q15904.2 |
| UniProt Secondary Accession: | Q15904,Q8NBT4, Q9H0C7, A6ZKI4, |
| UniProt Related Accession: | Q15904 |
| Molecular Weight: | 470 |
| NCBI Full Name: | V-type proton ATPase subunit S1 |
| NCBI Synonym Full Names: | ATPase, H+ transporting, lysosomal accessory protein 1 |
| NCBI Official Symbol: | ATP6AP1 |
| NCBI Official Synonym Symbols: | 16A; CF2; Ac45; XAP3; XAP-3; ATP6S1; VATPS1; ATP6IP1 |
| NCBI Protein Information: | V-type proton ATPase subunit S1; protein XAP-3; H-ATPase subunit; V-ATPase subunit S1; V-ATPase Ac45 subunit; V-ATPase S1 accessory protein; vacuolar proton pump subunit S1; ATPase, H+ transporting, lysosomal interacting protein 1; ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1 |
| UniProt Protein Name: | V-type proton ATPase subunit S1 |
| UniProt Synonym Protein Names: | Protein XAP-3; V-ATPase Ac45 subunit; V-ATPase S1 accessory protein; Vacuolar proton pump subunit S1 |
| Protein Family: | V-type proton ATPase |
| UniProt Gene Name: | ATP6AP1 |
| UniProt Entry Name: | VAS1_HUMAN |
