| UniProt Protein Function: | ATG4C: Cysteine protease required for autophagy, which cleaves the C-terminal part of either MAP1LC3, GABARAPL2 or GABARAP, allowing the liberation of form I. A subpopulation of form I is subsequently converted to a smaller form (form II). Form II, with a revealed C-terminal glycine, is considered to be the phosphatidylethanolamine (PE)-conjugated form, and has the capacity for the binding to autophagosomes. Highly expressed in skeletal muscle, heart, liver and testis. Inhibited by N-ethylmaleimide. Belongs to the peptidase C54 family. |
| UniProt Protein Details: | Protein type:Autophagy; Protease; Ubiquitin conjugating system; EC 3.4.22.- Chromosomal Location of Human Ortholog: 1p31.3 Cellular Component: cytoplasm; cytosol; extracellular region Molecular Function:cysteine-type endopeptidase activity; peptidase activity Biological Process: autophagic vacuole formation; autophagy; C-terminal protein lipidation; mitochondrion degradation; protein delipidation; protein processing; protein targeting to membrane; proteolysis |
| NCBI Summary: | Autophagy is the process by which endogenous proteins and damaged organelles are destroyed intracellularly. Autophagy is postulated to be essential for cell homeostasis and cell remodeling during differentiation, metamorphosis, non-apoptotic cell death, and aging. Reduced levels of autophagy have been described in some malignant tumors, and a role for autophagy in controlling the unregulated cell growth linked to cancer has been proposed. This gene encodes a member of the autophagin protein family. The encoded protein is also designated as a member of the C-54 family of cysteine proteases. Alternate transcriptional splice variants, encoding the same protein, have been characterized. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q96DT6 |
| NCBI GenInfo Identifier: | 61211867 |
| NCBI Gene ID: | 84938 |
| NCBI Accession: | Q96DT6.1 |
| UniProt Secondary Accession: | Q96DT6,Q96K04, A6NLR8, D3DQ58, |
| UniProt Related Accession: | Q96DT6 |
| Molecular Weight: | 52,497 Da |
| NCBI Full Name: | Cysteine protease ATG4C |
| NCBI Synonym Full Names: | autophagy related 4C cysteine peptidase |
| NCBI Official Symbol: | ATG4C |
| NCBI Official Synonym Symbols: | APG4C; AUTL1; AUTL3; APG4-C |
| NCBI Protein Information: | cysteine protease ATG4C |
| UniProt Protein Name: | Cysteine protease ATG4C |
| UniProt Synonym Protein Names: | AUT-like 3 cysteine endopeptidase; Autophagin-3; Autophagy-related cysteine endopeptidase 3; Autophagy-related protein 4 homolog C |
| Protein Family: | Cysteine protease |
| UniProt Gene Name: | ATG4C |
| UniProt Entry Name: | ATG4C_HUMAN |
