The Ataxin-10 Polyclonal Antibody (CAB4586) is a valuable tool for researchers studying Ataxin-10, a protein associated with spinocerebellar ataxia type 10 (SCA10), a neurodegenerative disorder. This antibody, produced in rabbits, is highly specific to human samples and has been validated for use in Western blot applications. By targeting the Ataxin-10 protein, this antibody enables researchers to detect and analyze its expression in a variety of cell types, making it an essential tool for studies in neurology and genetic diseases.Ataxin-10 is a key player in the pathogenesis of SCA10, making it a promising target for therapeutic interventions aimed at treating this debilitating condition.
The Ataxin-10 Polyclonal Antibody provides researchers with the means to explore the role of Ataxin-10 in disease progression and develop novel treatments that could potentially alleviate symptoms and improve the quality of life for individuals affected by SCA10. Understanding the molecular mechanisms underlying SCA10 is essential for advancing research efforts towards finding effective therapies for this disorder.
Product Name:
ATXN10 Rabbit Polyclonal Antibody
SKU:
CAB4586
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 346-475 of human ATXN10 (NP_037368.1).
This gene encodes a protein that may function in neuron survival, neuron differentiation, and neuritogenesis. These roles may be carried out via activation of the mitogen-activated protein kinase cascade. Expansion of an ATTCT repeat from 9-32 copies to 800-4500 copies in an intronic region of this locus has been associated with spinocerebellar ataxia, type 10. Alternatively spliced transcript variants have been described.
Purification Method:
Affinity purification
Gene ID:
25814
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using ATXN10 antibody (CAB4586) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
