Description
| 抗体名: | ASIP Antibody, FITC conjugated (PACO45680) |
| 抗体コード: | PACO45680 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA |
| 推奨される希釈: | |
| 反応性: | Human |
| 免疫原: | Recombinant Human Agouti-signaling protein (23-112AA) |
| 憲法: | Liquid |
| ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| 精製方法: | >95%, Protein G purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | FITC |
| バックグラウンド: | Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes. |
| シノニム: | Agouti-signaling protein (ASP) (Agouti switch protein), ASIP, AGTI AGTIL ASP |
| UniProt Protein Function: | ASIP: Involved in the regulation of melanogenesis. The binding of ASP to MC1R precludes alpha-MSH initiated signaling and thus blocks production of cAMP, leading to a down-regulation of eumelanogenesis (brown/black pigment) and thus increasing synthesis of pheomelanin (yellow/red pigment). In higher primates, agouti may affect the quality of hair pigmentation rather than its pattern of deposition. Could well play a role in neuroendocrine aspects of melanocortin action. May have some functional role in regulating the lipid metabolism with adipocytes. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 20q11.2-q12 Cellular Component: extracellular space Molecular Function:type 3 melanocortin receptor binding; type 4 melanocortin receptor binding; receptor binding Biological Process: melanin biosynthetic process; generation of precursor metabolites and energy; regulation of molecular function, epigenetic; hormone-mediated signaling; cell-cell signaling; melanosome organization and biogenesis; adult feeding behavior; signal transduction; melanosome transport Disease: Skin/hair/eye Pigmentation, Variation In, 9 |
| NCBI Summary: | In mice, the agouti gene encodes a paracrine signaling molecule that causes hair follicle melanocytes to synthesize pheomelanin, a yellow pigment, instead of the black or brown pigment, eumelanin. Pleiotropic effects of constitutive expression of the mouse gene include adult-onset obesity, increased tumor susceptibility, and premature infertility. This gene is highly similar to the mouse gene and encodes a secreted protein that may (1) affect the quality of hair pigmentation, (2) act as a pharmacological antagonist of alpha-melanocyte-stimulating hormone, (3) play a role in neuroendocrine aspects of melanocortin action, and (4) have a functional role in regulating lipid metabolism in adipocytes. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P42127 |
| NCBI GenInfo Identifier: | 1168389 |
| NCBI Gene ID: | 434 |
| NCBI Accession: | P42127.1 |
| UniProt Secondary Accession: | P42127,Q3SXL2, |
| UniProt Related Accession: | P42127 |
| Molecular Weight: | 132 |
| NCBI Full Name: | Agouti-signaling protein |
| NCBI Synonym Full Names: | agouti signaling protein |
| NCBI Official Symbol: | ASIP |
| NCBI Official Synonym Symbols: | ASP; AGSW; AGTI; AGTIL; SHEP9 |
| NCBI Protein Information: | agouti-signaling protein; nonagouti homolog; agouti switch protein; agouti signaling protein, nonagouti homolog |
| UniProt Protein Name: | Agouti-signaling protein |
| UniProt Synonym Protein Names: | Agouti switch protein |
| Protein Family: | Agouti-signaling protein |
| UniProt Gene Name: | ASIP |
| UniProt Entry Name: | ASIP_HUMAN |
