| UniProt Protein Function: | Function: Catalytic component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the APOB mRNA. Also involved in CGA (Arg) to UGA (Stop) editing in the NF1 mRNA. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Ref.8 |
| UniProt Protein Details: | Cofactor: Zinc By similarity. Subunit structure: Homodimer. Part of the apolipoprotein B mRNA editing complex with A1CF. Found in a complex with CELF2/CUGBP2 and A1CF. Interacts with HNRPAB and SYNCRIP. Ref.6 Ref.7 Subcellular location: Cytoplasm Ref.9. Tissue specificity: Expressed exclusively in the small intestine. Sequence similarities: Belongs to the cytidine and deoxycytidylate deaminase family. |
| NCBI Summary: | This gene encodes a member of the cytidine deaminase enzyme family. The encoded protein forms a multiple-protein editing holoenzyme with APOBEC1 complementation factor (ACF) and APOBEC1 stimulating protein (ASP). This holoenzyme is involved in the editing of C-to-U nucleotide bases in apolipoprotein B and neurofibromatosis-1 mRNAs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2015] |
| UniProt Code: | P41238 |
| NCBI GenInfo Identifier: | 61743957 |
| NCBI Gene ID: | 339 |
| NCBI Accession: | NP_001635 |
| UniProt Related Accession: | P41238 |
| Molecular Weight: | 28kDa |
| NCBI Full Name: | C->U-editing enzyme APOBEC-1 isoform a |
| NCBI Synonym Full Names: | apolipoprotein B mRNA editing enzyme catalytic subunit 1 |
| NCBI Official Symbol: | APOBEC1 |
| NCBI Official Synonym Symbols: | BEDP; HEPR; CDAR1; APOBEC-1 |
| NCBI Protein Information: | C->U-editing enzyme APOBEC-1 |
| UniProt Protein Name: | C->U-editing enzyme APOBEC-1 |
| UniProt Synonym Protein Names: | Apolipoprotein B mRNA-editing enzyme 1; HEPR |
| Protein Family: | APOBEC1 complementation factor |
| UniProt Gene Name: | APOBEC1 |
| UniProt Entry Name: | ABEC1_HUMAN |
