Description
| 抗体名: | APIP Antibody (PACO44534) |
| 抗体コード: | PACO44534 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB, IHC |
| 推奨される希釈: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
| 反応性: | Human, Mouse |
| 免疫原: | Recombinant Human Methylthioribulose-1-phosphate dehydratase protein (1-242AA) |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 精製方法: | Antigen Affinity Purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: APIPantibody at 1.85µg/ml. Lane 1: Mouse heart tissue. Lane 2: Mouse kidney tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 28, 23 kDa. Observed band size: 28 kDa.. |
 | Immunohistochemistry of paraffin-embedded human pancreatic tissue using PACO44534 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using PACO44534 at dilution of 1:100. |
| バックグラウンド: | Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death. |
| シノニム: | Methylthioribulose-1-phosphate dehydratase (MTRu-1-P dehydratase) (EC 4.2.1.109) (APAF1-interacting protein) (hAPIP), APIP |
| UniProt Protein Function: | MMRP19: Catalyzes the dehydration of methylthioribulose-1- phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1- phosphate (DK-MTP-1-P). Has an anti-apoptotic function and prevents muscle ischemic damage. Inhibits the cytochrome c- dependent and APAF1-mediated cell death. Belongs to the aldolase class II family. MtnB subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 4.2.1.109; Amino Acid Metabolism - cysteine and methionine; Apoptosis Chromosomal Location of Human Ortholog: 11p13 Cellular Component: cytoplasm Molecular Function:identical protein binding; 5-methylthioribulose-1-phosphate 4-dehydratase activity; protein binding; zinc ion binding Biological Process: methionine salvage; sulfur amino acid metabolic process; apoptosis; methionine biosynthetic process from S-adenosylmethionine; polyamine metabolic process; negative regulation of apoptosis |
| NCBI Summary: | APIP is an APAF1 (MIM 602233)-interacting protein that acts as a negative regulator of ischemic/hypoxic injury (Cho et al., 2004 [PubMed 15262985]).[supplied by OMIM, Dec 2008] |
| UniProt Code: | Q96GX9 |
| NCBI GenInfo Identifier: | 74731866 |
| NCBI Gene ID: | 51074 |
| NCBI Accession: | Q96GX9.1 |
| UniProt Secondary Accession: | Q96GX9,Q6PJX6, Q8WVU2, Q96HK2, Q9Y318, A8K9D3, |
| UniProt Related Accession: | Q96GX9 |
| Molecular Weight: | 242 |
| NCBI Full Name: | Methylthioribulose-1-phosphate dehydratase |
| NCBI Synonym Full Names: | APAF1 interacting protein |
| NCBI Official Symbol: | APIP |
| NCBI Official Synonym Symbols: | APIP2; CGI29; hAPIP; CGI-29; MMRP19 |
| NCBI Protein Information: | methylthioribulose-1-phosphate dehydratase; APIP; MTRu-1-P dehydratase; APAF1-interacting protein; probable methylthioribulose-1-phosphate dehydratase |
| UniProt Protein Name: | Methylthioribulose-1-phosphate dehydratase |
| UniProt Synonym Protein Names: | APAF1-interacting protein |
| UniProt Gene Name: | APIP |
| UniProt Entry Name: | MTNB_HUMAN |
