Description
| 抗体名: | AP3B1 Antibody (PACO07768) |
| 抗体コード: | PACO07768 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB |
| 推奨される希釈: | |
| 反応性: | Human, Mouse, Rat |
| 免疫原: | Human AP3B1 |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles. |
| 精製方法: | Antigen Affinity Purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
| シノニム: | adaptor-related protein complex 3, β 1 subunit;AP3B1;ADTB3;ADTB3A;HPS;HPS2;PE ; |
| UniProt Protein Function: | AP3B1: a subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. Mutations in AP3B1 cause defects of various cytoplasmic organelles including melanosomes, platelet dense granules and lysosomes, and are the cause of Hermansky-Pudlak syndrome 2. Two alternatively spliced isoforms have been described. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold; Vesicle Chromosomal Location of Human Ortholog: 5q14.1 Cellular Component: Golgi apparatus; membrane; lysosomal membrane; clathrin coated vesicle membrane Molecular Function:GTP-dependent protein binding; protein phosphatase binding Biological Process: intracellular protein transport; protein targeting to lysosome; melanosome organization and biogenesis; anterograde synaptic vesicle transport; antigen processing and presentation, exogenous lipid antigen via MHC class Ib; positive regulation of NK T cell differentiation; blood coagulation; anterograde axon cargo transport Disease: Hermansky-pudlak Syndrome 2 |
| NCBI Summary: | This gene encodes a protein that may play a role in organelle biogenesis associated with melanosomes, platelet dense granules, and lysosomes. The encoded protein is part of the heterotetrameric AP-3 protein complex which interacts with the scaffolding protein clathrin. Mutations in this gene are associated with Hermansky-Pudlak syndrome type 2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2012] |
| UniProt Code: | O00203 |
| NCBI GenInfo Identifier: | 254763431 |
| NCBI Gene ID: | 8546 |
| NCBI Accession: | O00203.3 |
| UniProt Secondary Accession: | O00203,O00580, Q7Z393, Q9HD66, E5RJ68, |
| UniProt Related Accession: | O00203 |
| Molecular Weight: | 116,195 Da |
| NCBI Full Name: | AP-3 complex subunit beta-1 |
| NCBI Synonym Full Names: | adaptor-related protein complex 3, beta 1 subunit |
| NCBI Official Symbol: | AP3B1 |
| NCBI Official Synonym Symbols: | PE; HPS; HPS2; ADTB3; ADTB3A |
| NCBI Protein Information: | AP-3 complex subunit beta-1; beta-3A-adaptin; AP-3 complex beta-3A subunit; adaptor protein complex AP-3 subunit beta-1; adaptor-related protein complex 3 subunit beta-1; clathrin assembly protein complex 3 beta-1 large chain |
| UniProt Protein Name: | AP-3 complex subunit beta-1 |
| UniProt Synonym Protein Names: | Adaptor protein complex AP-3 subunit beta-1; Adaptor-related protein complex 3 subunit beta-1; Beta-3A-adaptin; Clathrin assembly protein complex 3 beta-1 large chain |
| Protein Family: | AP-3 complex |
| UniProt Gene Name: | AP3B1 |
| UniProt Entry Name: | AP3B1_HUMAN |
