Description
| 抗体名: | ANXA7 Antibody (PACO43673) |
| 抗体コード: | PACO43673 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB, IHC |
| 推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200 |
| 反応性: | Human |
| 免疫原: | Recombinant Human Annexin A7 protein (259-488AA) |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 精製方法: | Antigen Affinity Purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: ANXA7 antibody at 4µg/ml. Lane 1: Jurkat whole cell lysate. Lane 2: LO2 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 53, 51 kDa. Observed band size: 53 kDa. |
 | Immunohistochemistry of paraffin-embedded human pancreatic tissue using PACO43673 at dilution of 1:100. |
 | Immunohistochemistry of paraffin-embedded human breast cancer using PACO43673 at dilution of 1:100. |
| バックグラウンド: | Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. |
| シノニム: | Annexin A7 (Annexin VII) (Annexin-7) (Synexin), ANXA7, ANX7 SNX |
| UniProt Protein Function: | ANXA7: Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. Interacts with PDCD6. Isoform 1 is expressed in brain, heart and skeletal muscle. Isoform 2 is more abundant in liver, lung, kidney, spleen, fibroblasts and placenta. Belongs to the annexin family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Calcium-binding; Motility/polarity/chemotaxis; Lipid-binding Chromosomal Location of Human Ortholog: 10q22.2 Cellular Component: endoplasmic reticulum membrane; membrane; plasma membrane; nuclear envelope; cytosol; nucleus Molecular Function:integrin binding; protein binding; calcium-dependent phospholipid binding; calcium ion binding; calcium-dependent protein binding Biological Process: cellular calcium ion homeostasis; regulation of cell shape; cell proliferation; cellular water homeostasis; epithelial cell differentiation; hemostasis; autophagy; social behavior; response to calcium ion; response to organic cyclic substance; response to salt stress |
| NCBI Summary: | Annexin VII is a member of the annexin family of calcium-dependent phospholipid binding proteins.The Annexin VII gene contains 14 exons and spans approximately 34 kb of DNA. An alternatively spliced cassette exon results in two mRNA transcripts of 2.0 and 2.4 kb which are predicted to generate two protein isoforms differing in their N-terminal domain. The alternative splicing event is tissue specific and the mRNA containing the cassette exon is prevalent in brain, heart and skeletal muscle. The transcripts also differ in their 3'-non coding regions by the use of two alternative poly(A) signals. Annexin VII encodes a protein with a molecular weight of approximately 51 kDa with a unique, highly hydrophobic N-terminal domain of 167 amino acids and a conserved C-terminal region of 299 amino acids. The latter domain is composed of alternating hydrophobic and hydrophilic segments. Structural analysis of the protein suggests that Annexin VII is a membrane binding protein with diverse properties, including voltage-sensitive calcium channel activity, ion selectivity and membrane fusion. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P20073 |
| NCBI GenInfo Identifier: | 215274186 |
| NCBI Gene ID: | 310 |
| NCBI Accession: | P20073.3 |
| UniProt Secondary Accession: | P20073,Q5F2H3, Q5T0M6, Q5T0M7, |
| UniProt Related Accession: | P20073 |
| Molecular Weight: | 488 |
| NCBI Full Name: | Annexin A7 |
| NCBI Synonym Full Names: | annexin A7 |
| NCBI Official Symbol: | ANXA7 |
| NCBI Official Synonym Symbols: | SNX; ANX7; SYNEXIN |
| NCBI Protein Information: | annexin A7; annexin-7; annexin VII |
| UniProt Protein Name: | Annexin A7 |
| UniProt Synonym Protein Names: | Annexin VII; Annexin-7; Synexin |
| UniProt Gene Name: | ANXA7 |
| UniProt Entry Name: | ANXA7_HUMAN |
