| UniProt Protein Function: | ANXA13: a calcium/phospholipid-binding protein associated with the cell membrane. ANXA13 is the probable common ancestor of the annexin family of proteins. Annexins all bind to phospholipids in a calcium-dependent manner. There are at least ten different annexins in mammalian species. Annexins do not contain signal peptides, yet some annexins (A1, A2 and A5) appear to be secreted in a physiologically regulated fashion. |
| UniProt Protein Details: | Protein type:Calcium-binding; Lipid-binding Chromosomal Location of Human Ortholog: 8q24.13 Cellular Component: nucleoplasm; extracellular space; basolateral plasma membrane; apical plasma membrane; plasma membrane; lipid raft Molecular Function:calcium-dependent phospholipid binding; phosphatidylserine binding; phosphatidylcholine binding; calcium ion binding Biological Process: negative regulation of Golgi to plasma membrane protein transport; positive regulation of Golgi to plasma membrane protein transport; cell differentiation |
| NCBI Summary: | This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. The specific function of this gene has not yet been determined; however, it is associated with the plasma membrane of undifferentiated, proliferating endothelial cells and differentiated villus enterocytes. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P27216 |
| NCBI GenInfo Identifier: | 281185504 |
| NCBI Gene ID: | 312 |
| NCBI Accession: | P27216.3 |
| UniProt Secondary Accession: | P27216,Q9BQR5, |
| UniProt Related Accession: | P27216 |
| Molecular Weight: | 39,744 Da |
| NCBI Full Name: | Annexin A13 |
| NCBI Synonym Full Names: | annexin A13 |
| NCBI Official Symbol: | ANXA13 |
| NCBI Official Synonym Symbols: | ISA; ANX13 |
| NCBI Protein Information: | annexin A13; annexin-13; annexin XIII; intestine-specific annexin; annexin, intestine-specific |
| UniProt Protein Name: | Annexin A13 |
| UniProt Synonym Protein Names: | Annexin XIII; Annexin-13; Intestine-specific annexin; ISA |
| Protein Family: | Annexin |
| UniProt Gene Name: | ANXA13 |
| UniProt Entry Name: | ANX13_HUMAN |
