The Anti-UBE2B Antibody (CAB0503) is a highly specific research tool designed for the detection and analysis of UBE2B, a key enzyme involved in the ubiquitination pathway. This antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding to the UBE2B protein, researchers can study its role in various cellular processes, making it an essential tool for studies in molecular biology and cancer research.UBE2B plays a crucial role in the ubiquitin-proteasome system, a pathway responsible for protein degradation and regulation.
Dysregulation of this pathway has been implicated in various diseases, including cancer and neurodegenerative disorders. By investigating the function of UBE2B, researchers can gain valuable insights into disease mechanisms and potentially identify novel therapeutic targets. The Anti-UBE2B Antibody is a valuable resource for scientists seeking to explore the intricate workings of the ubiquitination pathway and its implications in health and disease.
Product Name:
UBE2B Rabbit Monoclonal Antibody
SKU:
CAB0503
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 53-152 of human UBE2B (P63146).
The modification of proteins with ubiquitin is an important cellular mechanism for targeting abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E2 ubiquitin-conjugating enzyme family. This enzyme is required for post-replicative DNA damage repair. Its protein sequence is 100% identical to the mouse, rat, and rabbit homologs, which indicates that this enzyme is highly conserved in eukaryotic evolution.
Purification Method:
Affinity purification
Gene ID:
7320
Clone Number:
ARC2512
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of Rat testis, using UBE2B antibody (CAB0503) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
