The Anti-TTF1 Antibody (CAB3292) is a highly specific and sensitive tool for research on Thyroid transcription factor 1 (TTF1), a nuclear protein commonly used as a biomarker for thyroid and lung cancer. This antibody is produced in rabbits and is optimized for Western blot applications in human samples. TTF1 is a key transcription factor involved in the development and differentiation of thyroid and lung cells. It is also implicated in the regulation of genes related to pulmonary and thyroid function. The Anti-TTF1 Antibody binds specifically to TTF1, allowing for the detection and analysis of this important protein in various cell types.
Research involving TTF1 is essential for understanding the molecular mechanisms underlying thyroid and lung cancer development, as well as exploring potential therapeutic targets for these diseases. The Anti-TTF1 Antibody is a valuable tool for studies in oncology, endocrinology, and molecular biology, providing researchers with accurate and reliable results for their experiments.
Product Name:
TTF1 Rabbit Monoclonal Antibody
SKU:
CAB3292
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human NKX2-1 (P43699).
This gene encodes a protein initially identified as a thyroid-specific transcription factor. The encoded protein binds to the thyroglobulin promoter and regulates the expression of thyroid-specific genes but has also been shown to regulate the expression of genes involved in morphogenesis. Mutations and deletions in this gene are associated with benign hereditary chorea, choreoathetosis, congenital hypothyroidism, and neonatal respiratory distress, and may be associated with thyroid cancer. Multiple transcript variants encoding different isoforms have been found for this gene. This gene shares the symbol/alias 'TTF1' with another gene, transcription termination factor 1, which plays a role in ribosomal gene transcription.
Purification Method:
Affinity purification
Gene ID:
7080
Clone Number:
ARC1942
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using NKX2-1 Rabbit mAb (CAB3292) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
