The Anti-Sting Antibody (CAB20175) is a highly specific and sensitive tool for research involving the STING protein, a key player in innate immune signaling pathways. This polyclonal antibody, generated in rabbits, exhibits strong reactivity with human samples and has been validated for use in various experimental techniques, including Western blotting. By targeting the STING protein, this antibody enables precise detection and analysis of STING expression in various cell types, making it an invaluable tool for studies in immunology and infectious diseases.
STING, also known as stimulator of interferon genes, acts as a critical mediator of immune responses to pathogens and cellular stress. Dysregulation of STING signaling has been implicated in a wide range of diseases, including viral infections, autoimmune disorders, and inflammation-related conditions. Investigating the role of STING using this antibody can provide important insights into the mechanisms underlying these diseases and may lead to the development of novel therapeutic approaches targeting the STING pathway.
Product Name:
STING Rabbit Polyclonal Antibody
SKU:
CAB20175
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 280-371 of mouse STING. (NP_938023.1).
autophagosome, cytoplasm, cytosol, endoplasmic reticulum, endosome, Golgi apparatus, mitochondrial outer membrane, nucleoplasm, perinuclear region of cytoplasm, peroxisome, plasma membrane
Calculated MW:
43kDa
Observed MW:
33kDa/35kDa
Enables 2',3'-cyclic GMP-AMP binding activity; cyclic-di-GMP binding activity; and ubiquitin protein ligase binding activity. Involved in several processes, including defense response to other organism; macroautophagy; and positive regulation of interferon-beta production. Acts upstream of or within cellular response to interferon-beta; positive regulation of transcription by RNA polymerase II; and regulation of inflammatory response. Located in several cellular components, including autophagosome; perinuclear region of cytoplasm; and peroxisome. Is expressed in ductus deferens; epididymis; ileum; and prostate gland. Human ortholog(s) of this gene implicated in STING-associated vasculopathy with onset in infancy. Orthologous to human STING1 (stimulator of interferon response cGAMP interactor 1).
Purification Method:
Affinity purification
Gene ID:
72512
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using STING Rabbit pAb (CAB20175) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 5s.
