The Anti-Sestrin-1 Antibody (CAB19787) is a valuable tool for researchers studying Sestrin-1, a protein involved in regulating cellular metabolism and stress responses. This antibody, produced using cutting-edge technology, is highly specific to human samples and has been validated for use in various applications, including Western blotting and immunofluorescence.Sestrin-1 is a key player in cellular responses to various stressors, such as oxidative stress and nutrient deprivation, making it a crucial target for studies in aging, metabolic disorders, and cancer research.
By detecting and analyzing Sestrin-1 expression in different cell types, this antibody enables researchers to gain insights into the molecular mechanisms underlying these conditions and potentially identify therapeutic targets.With its high specificity and sensitivity, the Anti-Sestrin-1 Antibody (CAB19787) is a reliable tool for investigating the role of Sestrin-1 in physiological and pathological processes, providing valuable data for advancing our understanding of cellular homeostasis and disease pathology.
Product Name:
sestrin 1 Rabbit Monoclonal Antibody
SKU:
CAB19787
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 100-200 of human sestrin 1 (Q9Y6P5).
Cytoplasm, Cytosol, Fibrillar center, Nucleoplasm, Nucleus
Calculated MW:
57kDa
Observed MW:
66kDa
This gene encodes a member of the sestrin family. Sestrins are induced by the p53 tumor suppressor protein and play a role in the cellular response to DNA damage and oxidative stress. The encoded protein mediates p53 inhibition of cell growth by activating AMP-activated protein kinase, which results in the inhibition of the mammalian target of rapamycin protein. The encoded protein also plays a critical role in antioxidant defense by regenerating overoxidized peroxiredoxins, and the expression of this gene is a potential marker for exposure to radiation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
Purification Method:
Affinity purification
Gene ID:
27244
Clone Number:
ARC2313
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using sestrin 1 Rabbit mAb (CAB19787) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 180s.
