The SEC61A Antibody (CAB19795) is a valuable tool for researchers studying SEC61A, a critical component of the Sec61 translocon complex involved in protein translocation across the endoplasmic reticulum membrane. This polyclonal antibody, produced using rabbits as hosts, is highly specific to human SEC61A and is validated for use in Western blot applications.SEC61A is essential for the proper functioning of the protein translocation machinery, making it a key target for investigating cellular processes related to protein synthesis, folding, and trafficking. By binding to SEC61A, this antibody enables researchers to detect and study the expression levels and localization of SEC61A in various cell types, aiding in the understanding of its role in cellular function.
Research involving SEC61A is particularly relevant in the fields of cell biology, molecular biology, and protein biochemistry. By elucidating the mechanisms underlying protein translocation and quality control processes mediated by SEC61A, researchers can gain insights into various cellular pathways and diseases, including those related to ER stress, viral infections, and protein misfolding disorders. The SEC61A Antibody (CAB19795) provides a reliable tool for investigating these crucial biological processes and advancing scientific understanding in these areas.
Product Name:
Sec61A Rabbit Monoclonal Antibody
SKU:
CAB19795
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 350-450 of human Sec61A (Q9H9S3).
The protein encoded by this gene has similarity to a mouse protein which suggests a role in the insertion of secretory and membrane polypeptides into the endoplasmic reticulum. It may also be required for the assembly of membrane and secretory proteins. Alternative splicing results in multiple transcript variants.
Purification Method:
Affinity purification
Gene ID:
55176
Clone Number:
ARC2323
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of various cell lines, using Sec61A Rabbit mAb (CAB19795) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
