The REV-ERBα (NR1D1) Polyclonal Antibody (CAB20452) is a valuable tool for researchers studying the REV-ERBα protein, a key regulator of circadian rhythm and metabolism. This antibody, generated in rabbits, is highly specific to human samples and has been validated for use in Western blot and immunohistochemistry applications.REV-ERBα, a member of the nuclear receptor superfamily, plays a crucial role in the control of physiological processes such as metabolism, inflammation, and the sleep-wake cycle. Dysregulation of REV-ERBα has been linked to various metabolic disorders, making it a promising target for therapeutic interventions.
By utilizing the REV-ERBα Polyclonal Antibody, researchers can investigate the expression and localization of the REV-ERBα protein in different cell types and tissues. This antibody opens up new avenues for studying the molecular mechanisms underlying circadian rhythm regulation and metabolic pathways, providing insights that may lead to novel strategies for treating metabolic diseases and other related disorders.
Product Name:
Rev-Erbα/NR1D1 Rabbit Monoclonal Antibody
SKU:
CAB20452
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 280-360 of human Rev-Erbα/NR1D1 (NP_068370.1).
This gene encodes a transcription factor that is a member of the nuclear receptor subfamily 1. The encoded protein is a ligand-sensitive transcription factor that negatively regulates the expression of core clock proteins. In particular this protein represses the circadian clock transcription factor aryl hydrocarbon receptor nuclear translocator-like protein 1 (ARNTL). This protein may also be involved in regulating genes that function in metabolic, inflammatory and cardiovascular processes.
Purification Method:
Affinity purification
Gene ID:
9572
Clone Number:
ARC50483
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of lysates from Mouse liver, using Rev-Erbα/NR1D1 Rabbit mAb (CAB20452) at1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
