The Anti-PKM1-Specific Antibody (CAB18800) is an essential tool for researchers studying PKM1, a key enzyme involved in cellular energy metabolism. This polyclonal antibody, produced in rabbits, has high specificity for PKM1 and is validated for use in various applications, including Western blotting.PKM1 is a critical regulator of glycolysis, controlling the conversion of glucose into energy in cells. Dysregulation of PKM1 has been implicated in various diseases, such as cancer and metabolic disorders.
By detecting and analyzing PKM1 protein levels, this antibody facilitates the investigation of its role in these pathological conditions.The Anti-PKM1-Specific Antibody is valuable for researchers interested in understanding the molecular mechanisms underlying disease development and progression. Its high reactivity with human samples makes it a reliable tool for studies in cancer biology, metabolism, and other related fields.Unlock the potential of your research with the Anti-PKM1-Specific Antibody.
Product Name:
PKM1-specific Rabbit Polyclonal Antibody
SKU:
CAB18800
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 350-450 of human PKM1-specific (NP_001193728.1).
This gene encodes a protein involved in glycolysis. The encoded protein is a pyruvate kinase that catalyzes the transfer of a phosphoryl group from phosphoenolpyruvate to ADP, generating ATP and pyruvate. This protein has been shown to interact with thyroid hormone and may mediate cellular metabolic effects induced by thyroid hormones. This protein has been found to bind Opa protein, a bacterial outer membrane protein involved in gonococcal adherence to and invasion of human cells, suggesting a role of this protein in bacterial pathogenesis. Several alternatively spliced transcript variants encoding a few distinct isoforms have been reported.
Purification Method:
Affinity purification
Gene ID:
5315
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.01% thimerosal,50% glycerol,pH7.3.
Western blot analysis of various lysates using PKM1-specific Rabbit pAb (CAB18800) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
