The PITX3 Monoclonal Antibody (CAB19261) is developed for research purposes targeting PITX3, a transcription factor associated with the development and function of dopamine-producing neurons in the brain. The antibody, produced in mice, shows high specificity and sensitivity towards human samples and is suitable for use in various applications including immunofluorescence and immunohistochemistry.PITX3 is known for its crucial role in the development of midbrain dopaminergic neurons, making it a key player in the pathogenesis of Parkinson's disease and other neurodegenerative disorders. Research on PITX3 can provide insights into the mechanisms underlying neuronal differentiation and function, offering potential targets for therapeutic interventions aimed at treating neurological conditions.
By utilizing the PITX3 Monoclonal Antibody, researchers can effectively study the expression and localization of PITX3 in different cell types and tissues, enhancing our understanding of its function in normal brain development and neurodegenerative diseases. This antibody serves as a valuable tool for investigating the role of PITX3 in neuronal development and degeneration, contributing to advancements in neuroscience research and potential drug discovery efforts.
Product Name:
PITX3 Rabbit Monoclonal Antibody
SKU:
CAB19261
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human PITX3 (O75364).
This gene encodes a member of the RIEG/PITX homeobox family, which is in the bicoid class of homeodomain proteins. Members of this family act as transcription factors. This protein is involved in lens formation during eye development. Mutations of this gene have been associated with anterior segment mesenchymal dysgenesis and congenital cataracts.
Purification Method:
Affinity purification
Gene ID:
5309
Clone Number:
ARC2429
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using PITX3 Rabbit mAb (CAB19261) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 90s.
