Description
Anti-Phospho-TMEM173-S366 Antibody (CABP1223)
The Anti-Phospho-TMEM173 (S366) Polyclonal Antibody (CABP1223) is a valuable tool for researchers studying TMEM173, a protein involved in immune signaling pathways. This antibody, raised in rabbits, is specifically designed to target the phosphorylated form of TMEM173 at serine 366. It has been validated for use in Western blot applications and is highly reactive with human samples.TMEM173, also known as STING (Stimulator of Interferon Genes), is a key player in the innate immune response to viral and bacterial infections. Phosphorylation of TMEM173 at serine 366 is a crucial event in its activation, leading to the production of type I interferons and other pro-inflammatory cytokines.
This antibody enables researchers to detect and analyze the phosphorylation status of TMEM173 in various cell types, providing valuable insights into the mechanisms of immune response regulation.The significance of TMEM173 in immune signaling makes it a promising target for therapeutic intervention in infectious diseases, cancer, and autoimmune disorders. By understanding the phosphorylation events that regulate TMEM173 activity, researchers can develop novel strategies for modulating immune responses and potentially improving outcomes for patients with these conditions.
| Product Name: | Phospho-TMEM173-S366 Rabbit pAb |
| Product Code: | CABP1223 |
| Size: | 50uL, 100uL |
| Synonyms: | TMEM173, ERIS, MITA, MPYS, NET23, SAVI, STING, hMITA, hSTING |
| Applications: | WB |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding S366 of human TMEM173. |
| Applications: | WB |
| Recommended Dilutions: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | THP-1 |
| Immunogen: | A phospho specific peptide corresponding to residues surrounding S366 of human TMEM173. |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 340061 |
| Uniprot: | Q86WV6 |
| Observed MW: | 41KDa |
| UniProt Protein Function: | TMEM173: Facilitator of innate immune signaling that promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double- stranded DNA from viruses and bacteria delivered to the cytoplasm. Able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti- viral state following expression. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway. Associates with the MHC-II complex. Homodimer; 'Lys-63'-linked ubiquitination at Lys-150 is required for homodimerization. Interacts with DDX58/RIG-I, MAVS/VISA and SSR2. Interacts with RNF5 and TRIM56. Interacts with TBK1; when homodimer, leading to subsequent production of IFN-beta. Ubiquitously expressed. Belongs to the TMEM173 family. |
| UniProt Protein Details: | Protein type:Mitochondrial; Membrane protein, multi-pass; Apoptosis; Membrane protein, integral; Endoplasmic reticulum Chromosomal Location of Human Ortholog: 5q31.2 Cellular Component: Golgi apparatus; endoplasmic reticulum membrane; mitochondrial outer membrane; cytoplasmic vesicle membrane; perinuclear region of cytoplasm; plasma membrane; integral to membrane; peroxisome Molecular Function:identical protein binding; protein binding; protein homodimerization activity; ubiquitin protein ligase binding; transcription factor binding; protein kinase binding Biological Process: regulation of interferon type I production; positive regulation of protein binding; positive regulation of protein import into nucleus, translocation; apoptosis; positive regulation of interferon type I production; positive regulation of transcription factor import into nucleus; innate immune response; positive regulation of transcription from RNA polymerase II promoter; positive regulation of defense response to virus by host; activation of innate immune response; defense response to virus; interferon-beta production Disease: Sting-associated Vasculopathy, Infantile-onset |
| NCBI Summary: | This gene encodes a five transmembrane protein that functions as a major regulator of the innate immune response to viral and bacterial infections. The encoded protein is a pattern recognition receptor that detects cytosolic nucleic acids and transmits signals that activate type I interferon responses. The encoded protein has also been shown to play a role in apoptotic signaling by associating with type II major histocompatibility complex. Mutations in this gene are the cause of infantile-onset STING-associated vasculopathy. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014] |
| UniProt Code: | Q86WV6 |
| NCBI GenInfo Identifier: | 74727720 |
| NCBI Gene ID: | 340061 |
| NCBI Accession: | Q86WV6.1 |
| UniProt Secondary Accession: | Q86WV6,A8K3P6, B6EB35, D6RBX0, D6RE01, D6RID9, |
| UniProt Related Accession: | Q86WV6 |
| Molecular Weight: | Observed MW: 39kDa; Calculated MW 42kDa |
| NCBI Full Name: | Stimulator of interferon genes protein |
| NCBI Synonym Full Names: | transmembrane protein 173 |
| NCBI Official Symbol: | TMEM173 |
| NCBI Official Synonym Symbols: | ERIS; MITA; MPYS; SAVI; NET23; STING; hMITA; hSTING |
| NCBI Protein Information: | stimulator of interferon genes protein; endoplasmic reticulum IFN stimulator; mitochondrial mediator of IRF3 activation; endoplasmic reticulum interferon stimulator; N-terminal methionine-proline-tyrosine-serine plasma membrane tetraspanner |
| UniProt Protein Name: | Stimulator of interferon genes protein |
| UniProt Synonym Protein Names: | Endoplasmic reticulum interferon stimulator; ERIS; Mediator of IRF3 activation; hMITA; Transmembrane protein 173 |
| Protein Family: | Stimulator of interferon genes protein |
| UniProt Gene Name: | TMEM173 |
| UniProt Entry Name: | STING_HUMAN |
