The Anti-Phospho-Tau (T181) Antibody (CABP1234) is a valuable tool for researchers studying tau proteins and their phosphorylation states. Tau proteins play a crucial role in the formation of neurofibrillary tangles, a hallmark of neurodegenerative diseases like Alzheimer's. This antibody, generated in rabbits, specifically targets phosphorylated tau at the T181 site, enabling the detection and analysis of this important protein modification.Validated for use in Western blot applications, the Anti-Phospho-Tau (T181) Antibody (CABP1234) is highly reactive with human samples, providing researchers with a reliable tool for investigating tau pathology in neurological disorders.
By targeting phosphorylated tau at a specific site, this antibody offers insights into the mechanisms underlying tau aggregation and its role in disease progression.Whether studying Alzheimer's disease, tauopathies, or other neurodegenerative conditions, the Anti-Phospho-Tau (T181) Antibody (CABP1234) is a valuable resource for researchers seeking to understand the role of tau phosphorylation in disease development and progression. Its specificity and sensitivity make it an essential tool for advancing our knowledge of tau biology and its implications for therapeutic interventions.
Product Name:
Phospho-Tau-T181 Rabbit Polyclonal Antibody
SKU:
CABP1234
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
A synthetic phosphorylated peptide around T181 of human Tau (NP_001190181.1).
This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy.
Purification Method:
Affinity purification
Gene ID:
4137
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.05% proclin300,50% glycerol,pH7.3.
Western blot analysis of various lysates, using Phospho-Tau-T181 Rabbit pAb (CABP1234) at 1:600 dilution.Mouse brain cells were treated by λ-PP mixed solution (1ul) at 30℃ for 30 minutes.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
