The Anti-Phospho CREB1 (S142) Antibody (CABP0334) is a vital tool for researchers studying CREB1, a key transcription factor involved in gene expression regulation. This polyclonal antibody, produced in rabbits, is highly specific and reacts well with human samples, making it suitable for Western blot applications. By targeting the phosphorylated form of CREB1 at serine 142, this antibody allows for precise detection and analysis of the protein in various cell types.CREB1, a phosphorylated protein, plays a crucial role in a variety of cellular processes including cell survival, proliferation, and neuronal plasticity. Phosphorylation of CREB1 at serine 142 is known to enhance its transcriptional activity, making it an important post-translational modification for regulating gene expression.
Understanding the phosphorylation status of CREB1 is essential for unraveling its functional significance and potential implications in diseases such as cancer, neurodegenerative disorders, and metabolic conditions.With its specificity and reliability, the Anti-Phospho CREB1 (S142) Antibody (CABP0334) is a valuable tool for researchers delving into the intricate mechanisms of gene regulation and cellular signaling pathways involving CREB1. Its versatility in different cell types and its ability to detect phosphorylated CREB1 make it a key component in advancing research in fields like molecular biology, neuroscience, and cancer biology.
Product Name:
Phospho-CREB1-S142 Rabbit Polyclonal Antibody
SKU:
CABP0334
Size:
100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A phospho specific peptide corresponding to residues surrounding S142 of human CREB1
Tested Applications:
WB
Recommended Dilution:
WB,1:500 - 1:1000
Synonyms:
CREB; CREB-1; Phospho-CREB1-S142
Conjugate:
Unconjugated
Cellular Localization:
Nucleus.
Calculated MW:
35kDa
Observed MW:
Refer to Figures
This gene encodes a transcription factor that is a member of the leucine zipper family of DNA binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in several transcript variants encoding different isoforms.
Purification Method:
Affinity purification
Gene ID:
1385
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.
