The Anti-Nesprin-1 Antibody (CAB19781) is a valuable tool for researchers studying nesprin-1, a key protein involved in nuclear positioning and mechanotransduction. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the nesprin-1 protein, researchers can accurately detect and analyze its expression in various cell types.Nesprin-1 is a component of the LINC (linker of nucleoskeleton and cytoskeleton) complex, which plays a crucial role in maintaining nuclear organization and responding to mechanical cues in the cell environment.
Understanding the function of nesprin-1 is essential for investigating cellular processes such as cell migration, cell division, and gene expression regulation.Research involving nesprin-1 has implications for fields such as cell biology, cancer biology, and tissue engineering. By using the Anti-Nesprin-1 Antibody, scientists can further explore the intricate mechanisms by which nesprin-1 influences cellular behavior and potentially uncover new therapeutic targets for diseases related to nuclear positioning and mechanotransduction dysfunction.
Product Name:
Nesprin 1 Rabbit Monoclonal Antibody
SKU:
CAB19781
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse
Immunogen:
Recombinant fusion protein containing a sequence corresponding to amino acids 8200-8400 of human Nesprin 1 (Q8NF91).
This gene encodes a spectrin repeat containing protein expressed in skeletal and smooth muscle, and peripheral blood lymphocytes, that localizes to the nuclear membrane. Mutations in this gene have been associated with autosomal recessive spinocerebellar ataxia 8, also referred to as autosomal recessive cerebellar ataxia type 1 or recessive ataxia of Beauce. Alternatively spliced transcript variants encoding different isoforms have been described.
Purification Method:
Affinity purification
Gene ID:
23345
Clone Number:
ARC2307
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using Nesprin 1 Rabbit mAb (CAB19781) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates / proteins: 25 μg per lane.Blocking buffer: 3 % nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
