The LMAN1 Monoclonal Antibody (CAB4941) is a valuable tool for researchers studying LMAN1, a protein involved in the transport of secretory proteins from the endoplasmic reticulum to the Golgi apparatus. This antibody, produced in mice, is highly specific to human LMAN1 and is validated for use in various applications, including immunofluorescence and flow cytometry.LMAN1 is essential for proper protein trafficking and secretion, making it a key player in cell biology and protein homeostasis. Dysregulation of LMAN1 function has been linked to various diseases, including neurodegenerative disorders and certain types of cancer.
By using the LMAN1 antibody, researchers can study the expression and localization of LMAN1 in different cell types, shedding light on its role in disease pathology and potentially identifying new therapeutic targets.Overall, the LMAN1 Monoclonal Antibody is a valuable tool for investigating the function of LMAN1 in health and disease, providing researchers with a deeper understanding of protein trafficking pathways and their implications for human health.
Product Name:
LMAN1 Rabbit Monoclonal Antibody
SKU:
CAB4941
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human LMAN1 (P49257).
Endoplasmic reticulum membrane, Endoplasmic reticulum-Golgi intermediate compartment membrane, Golgi apparatus membrane, Single-pass membrane protein, Single-pass type I membrane protein.
Calculated MW:
54kDa
Observed MW:
58kDa
The protein encoded by this gene is a membrane mannose-specific lectin that cycles between the endoplasmic reticulum, endoplasmic reticulum-Golgi intermediate compartment, and cis-Golgi, functioning as a cargo receptor for glycoprotein transport. The protein has an N-terminal signal sequence, a calcium-dependent and pH-sensitive carbohydrate recognition domain, a stalk region that functions in oligomerization, a transmembrane domain, and a short cytoplasmic domain required for organelle targeting. Allelic variants of this gene are associated with the autosomal recessive disorder combined factor V-factor VIII deficiency.
Purification Method:
Affinity purification
Gene ID:
3998
Clone Number:
ARC1978
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using LMAN1 Rabbit mAb (CAB4941) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
