The Anti-Dystrophin Antibody (CAB4746) is a valuable tool for researchers studying dystrophin, a protein critical for maintaining muscle cell structure and function. This polyclonal antibody, produced in rabbits, specifically targets dystrophin in human samples and is suitable for use in Western blot applications.Dystrophin is essential for muscle cell stability, and mutations in the dystrophin gene can lead to various forms of muscular dystrophy. By utilizing the Anti-Dystrophin Antibody, researchers can investigate the expression levels and localization of dystrophin in different cell types, aiding in the understanding of muscle biology and potential therapeutic targets for muscular dystrophy.
The Anti-Dystrophin Antibody is a valuable tool for research in the fields of muscle biology, neuromuscular diseases, and therapeutic development. Its high reactivity and specificity make it a reliable option for studying dystrophin and its role in muscle function.
Product Name:
Dystrophin Rabbit Monoclonal Antibody
SKU:
CAB4746
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 3586-3685 of human Dystrophin (P11532).
This gene spans a genomic range of greater than 2 Mb and encodes a large protein containing an N-terminal actin-binding domain and multiple spectrin repeats. The encoded protein forms a component of the dystrophin-glycoprotein complex (DGC), which bridges the inner cytoskeleton and the extracellular matrix. Deletions, duplications, and point mutations at this gene locus may cause Duchenne muscular dystrophy (DMD), Becker muscular dystrophy (BMD), or cardiomyopathy. Alternative promoter usage and alternative splicing result in numerous distinct transcript variants and protein isoforms for this gene.
Purification Method:
Affinity purification
Gene ID:
1756
Clone Number:
ARC1118
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Immunohistochemistry analysis of paraffin-embedded Rat skeletal muscle using Dystrophin Rabbit mAb (CAB4746) at dilution of 1:100 (40x lens).Perform microwave antigen retrieval with 10 mM PBS buffer pH 7.2 before commencing with IHC staining protocol.
