The Anti-Cytokeratin 6 (KRT6) Antibody (CAB4631) is a valuable tool for researchers studying cytokeratin 6, a type II intermediate filament protein expressed in epithelial tissues. This antibody, raised in rabbits, is highly specific to human samples and is validated for use in a variety of applications, including immunohistochemistry and Western blotting.Cytokeratin 6 is involved in maintaining the structural integrity of epithelial cells and is upregulated in response to various forms of epithelial stress. Research involving cytokeratin 6 is important for understanding its role in diseases such as cancer, where aberrant expression of this protein can be a marker for tumor progression.
The Anti-Cytokeratin 6 Antibody (CAB4631) allows for precise detection and analysis of cytokeratin 6 in different cell types, making it an essential tool for studies in cancer biology, tissue engineering, and regenerative medicine. Its high specificity and sensitivity make it a reliable choice for researchers looking to explore the functions of cytokeratin 6 in health and disease.
Product Name:
Cytokeratin 6 (KRT6) Rabbit Monoclonal Antibody
SKU:
CAB4631
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Cytokeratin 6 (KRT6) (P02538).
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. As many as six of this type II cytokeratin (KRT6) have been identified; the multiplicity of the genes is attributed to successive gene duplication events. The genes are expressed with family members KRT16 and/or KRT17 in the filiform papillae of the tongue, the stratified epithelial lining of oral mucosa and esophagus, the outer root sheath of hair follicles, and the glandular epithelia. This KRT6 gene in particular encodes the most abundant isoform. Mutations in these genes have been associated with pachyonychia congenita. In addition, peptides from the C-terminal region of the protein have antimicrobial activity against bacterial pathogens. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.
Purification Method:
Affinity purification
Gene ID:
3853
Clone Number:
ARC2142
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using Cytokeratin 6 (KRT6) (KRT6) Rabbit mAb (CAB4631) at 1:3000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
