The Anti-Cytokeratin 4 (KRT4) Antibody (CAB0013) is a high-quality polyclonal antibody specifically designed for research involving cytokeratin 4 (KRT4), a protein involved in maintaining the structural integrity of epithelial cells. This antibody, generated in rabbits, exhibits strong reactivity with human samples and has been validated for use in Western blot applications, enabling the detection and analysis of KRT4 in various cell types.Cytokeratin 4 is a critical component of the cytoskeleton in epithelial cells, playing a key role in cell structure and function. Aberrant expression or mutations in KRT4 have been implicated in various diseases, including cancer and skin disorders.
By targeting KRT4, researchers can gain valuable insights into the molecular mechanisms underlying these conditions and potentially identify novel therapeutic targets.The Anti-Cytokeratin 4 (KRT4) Antibody (CAB0013) is an essential tool for studying the functions and dysregulation of KRT4 in different biological contexts, making it ideal for investigations in cell biology, oncology, and dermatology. Its high specificity and sensitivity make it a valuable asset for researchers seeking to unravel the complexities of epithelial cell biology and its role in disease development.
Product Name:
Cytokeratin 4 (KRT4) Rabbit Monoclonal Antibody
SKU:
CAB0013
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 1-100 of human Cytokeratin 4 (KRT4) (P19013).
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in differentiated layers of the mucosal and esophageal epithelia with family member KRT13. Mutations in these genes have been associated with White Sponge Nevus, characterized by oral, esophageal, and anal leukoplakia. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.
Purification Method:
Affinity purification
Gene ID:
3851
Clone Number:
ARC1804
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using Cytokeratin 4 (KRT4) (KRT4) Rabbit mAb (CAB0013) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 30s.
