The Anti-Cytokeratin 1 (KRT1) Antibody (CAB9776) is a valuable tool for researchers studying cytokeratin 1, a type I cytokeratin protein involved in the structural integrity of epithelial cells. This antibody, produced in rabbits, exhibits high specificity towards human samples and is suitable for various immunological techniques such as Western blotting. By binding to cytokeratin 1, researchers can effectively analyze and detect this protein in different cell types, making it particularly useful for investigations in cell biology and cancer research.
Cytokeratin 1 is a key component of the cytoskeleton in epithelial cells and is crucial for maintaining cell structure and function. Abnormalities in cytokeratin expression have been linked to various cancers, making it a potential biomarker for cancer diagnosis and prognosis. Understanding the role of cytokeratin 1 in cell biology and disease pathogenesis is essential for developing targeted therapies and diagnostic tools for cancer and other related conditions.
Product Name:
Cytokeratin 1 (KRT1) Rabbit Monoclonal Antibody
SKU:
CAB9776
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 545-644 of human Cytokeratin 1 (KRT1) (P04264).
The protein encoded by this gene is a member of the keratin gene family. The type II cytokeratins consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. This type II cytokeratin is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma. The type II cytokeratins are clustered in a region of chromosome 12q12-q13.
Purification Method:
Affinity purification
Gene ID:
3848
Clone Number:
ARC1745
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using Cytokeratin 1 (KRT1) (KRT1) Rabbit mAb (CAB9776) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
