Description
Anti-Casein Kinase 1 alpha (CSNK1A1) Antibody (CAB9308)
The Anti-Casein Kinase 1 Alpha (CSNK1A1) Antibody (CAB9308) is a valuable tool for research involving the CSNK1A1 protein, a key regulator of cellular signaling pathways. This polyclonal antibody, generated in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By specifically targeting the CSNK1A1 protein, this antibody enables precise detection and analysis in a variety of cell types, making it ideal for studies in molecular biology, cell signaling, and cancer research.CSNK1A1, also known as casein kinase 1 alpha, plays a crucial role in diverse cellular processes such as cell proliferation, differentiation, and metabolism.
Its dysregulation has been implicated in various diseases including cancer, neurological disorders, and metabolic syndromes. Investigating the function of CSNK1A1 is essential for understanding its role in disease pathogenesis and identifying potential therapeutic targets for intervention.Overall, the Anti-Casein Kinase 1 Alpha (CSNK1A1) Antibody (CAB9308) is a valuable tool for researchers aiming to unravel the intricacies of cellular signaling pathways and explore the therapeutic potential of targeting CSNK1A1 in the treatment of various diseases.
| Product Name: | Casein Kinase 1 alpha (CSNK1A1) Rabbit mAb |
| Product Code: | CAB9308 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | CK1, CK1a, CKIa, HEL-S-77p, HLCDGP1, PRO2975 |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human Casein Kinase 1 alpha (Casein Kinase 1 alpha (CSNK1A1)) |
| Applications: | WB, IHC |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HeLa, NIH/3T3, Jurkat, Mouse lung, Rat lung, Rat brain |
| Immunogen: | A synthesized peptide derived from human Casein Kinase 1 alpha (Casein Kinase 1 alpha (CSNK1A1)) |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 1452 |
| Uniprot: | P48729 |
| Cellular Location: | Chromosome, Cytoplasm, Nucleus speckle, centromere, centrosome, cytoskeleton, kinetochore, microtubule organizing center |
| Calculated MW: | 35kDa |
| Observed MW: | 35kDa |
| UniProt Protein Function: | CK1A: an ubiquitous protein kinase of the CK1 family. Participates in Wnt signaling. Phosphorylates beta catenin, marking it for beta-TRCp-mediated ubiquitinylation and proteasomal degradation. |
| UniProt Protein Details: | Protein type:Protein kinase, CK1; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); Kinase, protein; CK1 group; CK1 family Chromosomal Location of Human Ortholog: 5q32 Cellular Component: beta-catenin destruction complex; centrosome; cytosol; keratin filament; membrane; mRNA cleavage and polyadenylation specificity factor complex; nuclear speck Molecular Function:kinase activity; protein binding; protein kinase activity; protein serine/threonine kinase activity Biological Process: cell surface receptor linked signal transduction; Golgi organization and biogenesis; intermediate filament cytoskeleton organization and biogenesis; peptidyl-serine phosphorylation; phagocytosis; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; proteasomal ubiquitin-dependent protein catabolic process; protein amino acid phosphorylation; regulation of cell shape; Wnt receptor signaling pathway |
| UniProt Code: | P48729 |
| NCBI GenInfo Identifier: | 31077177 |
| NCBI Gene ID: | 1452 |
| NCBI Accession: | P48729.2 |
| UniProt Secondary Accession: | P48729,Q4JJA0, Q5U046, Q5U047, Q6FGA2, Q71TU5, Q96HD2 Q9UDK3, D3DQG0, D3DQG1, |
| UniProt Related Accession: | P48729 |
| Molecular Weight: | 37,567 Da |
| NCBI Full Name: | Casein kinase I isoform alpha |
| NCBI Synonym Full Names: | casein kinase 1 alpha 1 |
| NCBI Official Symbol: | CSNK1A1 |
| NCBI Official Synonym Symbols: | CK1; CK1a; CKIa; HLCDGP1; PRO2975; HEL-S-77p |
| NCBI Protein Information: | casein kinase I isoform alpha |
| UniProt Protein Name: | Casein kinase I isoform alpha |
| UniProt Synonym Protein Names: | CK1 |
| Protein Family: | Casein kinase |
| UniProt Gene Name: | CSNK1A1 |
| UniProt Entry Name: | KC1A_HUMAN |
