The Anti-ACVR1 Antibody (CAB19274) is a high-quality polyclonal antibody designed for research involving ACVR1, a cell surface molecule involved in various biological processes, including cell growth and differentiation. The antibody, raised in rabbits, is highly specific and reactive with human samples, making it ideal for use in a variety of research applications.ACVR1, also known as activin receptor type-1, plays a crucial role in the TGF-beta signaling pathway, which is involved in regulating cell growth, development, and immune responses. Dysregulation of ACVR1 has been implicated in various diseases, including cancer and developmental disorders.
By targeting ACVR1 with this antibody, researchers can study its role in these disease processes and potentially identify new therapeutic targets.Overall, the Anti-ACVR1 Antibody (CAB19274) offers researchers a valuable tool for studying the function of ACVR1 and its implications in various biological processes and diseases. Its high specificity and reactivity make it a reliable choice for studies in immunology, cancer research, and developmental biology.
Product Name:
ACVR1 Rabbit Monoclonal Antibody
SKU:
CAB19274
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 410-509 of human ACVR1 (Q04771).
Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive.
Purification Method:
Affinity purification
Gene ID:
90
Clone Number:
ARC2449
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of extracts of Mouse brain, using ACVR1 antibody (CAB19274) at1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 1s.
