Similarly, the Anti-67kDa Laminin Receptor Antibody (CAB5968) offered by Assay Genie is a valuable tool for researchers interested in studying the 67kDa laminin receptor (67LR). This polyclonal antibody, produced in rabbits, is highly specific and reacts strongly with human samples. It is suitable for use in techniques such as Western blotting, immunohistochemistry, and immunofluorescence.The 67kDa laminin receptor, also known as LRP/LR or RPSA, is a multifunctional protein involved in various cellular processes, including cell adhesion, migration, and signaling. It has been implicated in cancer progression, metastasis, and angiogenesis, making it a promising target for cancer research and therapeutics.
By using the Anti-67kDa Laminin Receptor Antibody, researchers can detect and analyze 67LR expression in different cell types and tissues, providing valuable insights into its role in cancer biology and potential therapeutic interventions.This antibody is a valuable tool for investigators studying the molecular mechanisms underlying cancer progression, as well as those exploring the potential of targeting the 67kDa laminin receptor for cancer therapy. Its high specificity and sensitivity make it a reliable choice for researchers looking to advance our understanding of this important protein and its implications in cancer biology.
Product Name:
67kDa Laminin Receptor Rabbit Monoclonal Antibody
SKU:
CAB5968
Size:
20uL, 100uL
Isotype:
IgG
Host Species:
Rabbit
Reactivity:
Human,Mouse,Rat
Immunogen:
A synthetic peptide corresponding to a sequence within amino acids 196-295 of human Laminin Receptor (P08865).
Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene.
Purification Method:
Affinity purification
Gene ID:
3921
Clone Number:
ARC2109
Storage Buffer:
Store at -20℃. Avoid freeze / thaw cycles.Buffer: PBS with 0.02% sodium azide,0.05% BSA,50% glycerol,pH7.3.
Western blot analysis of various lysates using 67kDa Laminin Receptor Rabbit mAb (CAB5968) at 1:1000 dilution.Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution.Lysates/proteins: 25μg per lane.Blocking buffer: 3% nonfat dry milk in TBST.Detection: ECL Basic Kit (AbGn00020).Exposure time: 10s.
