Description
| 抗体名: | ALKBH4 Antibody, HRP conjugated (PACO48163) |
| 抗体コード: | PACO48163 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA |
| 推奨される希釈: | |
| 反応性: | Human |
| 免疫原: | Recombinant Human Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 protein (1-115AA) |
| 憲法: | Liquid |
| ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| 精製方法: | >95%, Protein G purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | HRP |
| バックグラウンド: | Dioxygenase that mediates demethylation of actin monomethylated at 'Lys-84' (K84me1), thereby acting as a regulator of actomyosin-processes. Demethylation of actin K84me1 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration. May be involved in transcription regulation. |
| シノニム: | Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 (EC 1.14.11) (Alkylated DNA repair protein alkB homolog 4), ALKBH4, ABH4 |
| UniProt Protein Function: | ALKBH4: Probable dioxygenase that requires molecular oxygen, alpha-ketoglutarate and iron. Belongs to the alkB family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 1.14.11.- Chromosomal Location of Human Ortholog: 7q22.1 Cellular Component: cytoplasm; midbody; nucleus Molecular Function:metal ion binding; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors; actin binding; demethylase activity Biological Process: transcription, DNA-dependent; regulation of transcription, DNA-dependent; actomyosin structure organization and biogenesis; protein amino acid demethylation |
| UniProt Code: | Q9NXW9 |
| NCBI GenInfo Identifier: | 74734701 |
| NCBI Gene ID: | 54784 |
| NCBI Accession: | Q9NXW9.1 |
| UniProt Related Accession: | Q9NXW9 |
| Molecular Weight: | |
| NCBI Full Name: | Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 |
| NCBI Synonym Full Names: | alkB homolog 4, lysine demethylase |
| NCBI Official Symbol: | ALKBH4 |
| NCBI Official Synonym Symbols: | ABH4 |
| NCBI Protein Information: | alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 |
| UniProt Protein Name: | Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 |
| UniProt Synonym Protein Names: | Alkylated DNA repair protein alkB homolog 4 |
| UniProt Gene Name: | ALKBH4 |
| UniProt Entry Name: | ALKB4_HUMAN |
