| UniProt Protein Function: | ALKBH2: Dioxygenase that repairs alkylated DNA and RNA containing 1-methyladenine and 3-methylcytosine by oxidative demethylation. Can also repair alkylated DNA containing 1- ethenoadenine (in vitro). Has strong preference for double- stranded DNA. Has low efficiency with single-stranded substrates. Requires molecular oxygen, alpha-ketoglutarate and iron. Belongs to the alkB family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:DNA repair, damage; EC 1.14.11.33; Oxidoreductase; Hydrolase; Demethylase Chromosomal Location of Human Ortholog: 12q24.11 Cellular Component: microtubule cytoskeleton; nucleoplasm; nucleus Molecular Function:ferrous iron binding; DNA-N1-methyladenine dioxygenase activity; DNA demethylase activity Biological Process: DNA dealkylation; DNA repair |
| NCBI Summary: | The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 and ALKBH3 (MIM 610603) are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q6NS38 |
| NCBI GenInfo Identifier: | 74736661 |
| NCBI Gene ID: | 121642 |
| NCBI Accession: | Q6NS38.1 |
| UniProt Related Accession: | Q6NS38 |
| Molecular Weight: | |
| NCBI Full Name: | DNA oxidative demethylase ALKBH2 |
| NCBI Synonym Full Names: | alkB homolog 2, alpha-ketoglutarate dependent dioxygenase |
| NCBI Official Symbol: | ALKBH2 |
| NCBI Official Synonym Symbols: | ABH2 |
| NCBI Protein Information: | DNA oxidative demethylase ALKBH2 |
| UniProt Protein Name: | Alpha-ketoglutarate-dependent dioxygenase alkB homolog 2 |
| UniProt Synonym Protein Names: | Alkylated DNA repair protein alkB homolog 2; DNA oxidative demethylase ALKBH2; Oxy DC1 |
| Protein Family: | Alkane 1-monooxygenase |
| UniProt Gene Name: | ALKBH2 |
| UniProt Entry Name: | ALKB2_HUMAN |
