Description
| 抗体名: | AKR1C1 Antibody (PACO55386) |
| 抗体コード: | PACO55386 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, IF |
| 推奨される希釈: | ELISA:1:2000-1:10000, IF:1:50-1:200 |
| 反応性: | Human |
| 免疫原: | Recombinant Human Aldo-keto reductase family 1 member C1 protein (219-323AA) |
| 憲法: | Liquid |
| ストレージバッファ: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
| 精製方法: | >95%, Protein G purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Immunofluorescence staining of HepG2 cells with PACO55386 at 1:100, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
| バックグラウンド: | Converts progesterone to its inactive form, 20-alpha-dihydroxyprogesterone (20-alpha-OHP). In the liver and intestine, may have a role in the transport of bile. May have a role in monitoring the intrahepatic bile acid, concentration. Has a low bile-binding ability. May play a role in myelin formation. |
| シノニム: | Aldo-keto reductase family 1 member C1 (EC 1.1.1) (20-alpha-hydroxysteroid dehydrogenase) (20-alpha-HSD) (EC 1.1.1.149) (Chlordecone reductase homolog HAKRC) (Dihydrodiol dehydrogenase 1/2) (DD1/DD2) (High-affinity hepatic bile acid, binding protein) (HBAB) (Indanol dehydrogenase) (EC 1.1.1.112) (Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase) (EC 1.3.1.20), AKR1C1, DDH DDH1 |
| UniProt Protein Function: | Converts progesterone to its inactive form, 20-alpha-dihydroxyprogesterone (20-alpha-OHP). In the liver and intestine, may have a role in the transport of bile. May have a role in monitoring the intrahepatic bile acid concentration. Has a low bile-binding ability. May play a role in myelin formation. |
| NCBI Summary: | This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. These enzymes catalyze the conversion of aldehydes and ketones to their corresponding alcohols by utilizing NADH and/or NADPH as cofactors. The enzymes display overlapping but distinct substrate specificity. This enzyme catalyzes the reaction of progesterone to the inactive form 20-alpha-hydroxy-progesterone. This gene shares high sequence identity with three other gene members and is clustered with those three genes at chromosome 10p15-p14. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q04828 |
| NCBI GenInfo Identifier: | 416877 |
| NCBI Gene ID: | 1645 |
| NCBI Accession: | Q04828.1 |
| UniProt Secondary Accession: | Q04828,P52896, Q5SR15, Q7M4N2, Q9UCX2, |
| UniProt Related Accession: | Q04828 |
| Molecular Weight: | 36 kDa |
| NCBI Full Name: | Aldo-keto reductase family 1 member C1 |
| NCBI Synonym Full Names: | aldo-keto reductase family 1 member C1 |
| NCBI Official Symbol: | AKR1C1 |
| NCBI Official Synonym Symbols: | C9; DD1; DDH; DDH1; H-37; HBAB; MBAB; HAKRC; DD1/DD2; 2-ALPHA-HSD; 20-ALPHA-HSD |
| NCBI Protein Information: | aldo-keto reductase family 1 member C1 |
| UniProt Protein Name: | Aldo-keto reductase family 1 member C1 |
| UniProt Synonym Protein Names: | 20-alpha-hydroxysteroid dehydrogenase (EC:1.1.1.149 |
| Protein Family: | Aldo-keto reductase family |
| UniProt Gene Name: | AKR1C1 |
| Antibodies | ELISA Kits |
| Anti-AKR1C1 Antibody (CAB13004) | Human AKR1C1 ELISA Kit |
| AKR1C1 Antibody (PACO03563) | Human Aldo-keto reductase family 1 member C1 (AKR1C1) ELISA Kit |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
