Description
| 抗体名: | AKAP12 Antibody (PACO18924) |
| 抗体コード: | PACO18924 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, IHC |
| 推奨される希釈: | ELISA:1:3000-1:10000, IHC:1:50-1:200 |
| 反応性: | Human |
| 免疫原: | Synthetic peptide of human AKAP12 |
| 憲法: | Liquid |
| ストレージバッファ: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| 精製方法: | Antigen affinity purification |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human lung cancer tissue using PACO18924(AKAP12 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human brain tissue using PACO18924(AKAP12 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
| バックグラウンド: | The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is expressed in endothelial cells, cultured fibroblasts, and osteosarcoma cells. It associates with protein kinases A and C and phosphatase, and serves as a scaffold protein in signal transduction. This protein and RII PKA colocalize at the cell periphery. This protein is a cell growth-related protein. Antibodies to this protein can be produced by patients with myasthenia gravis. Alternative splicing of this gene results in two transcript variants encoding different isoforms. |
| シノニム: | A kinase (PRKA) anchor protein 12 |
| UniProt Protein Function: | SSTR1: Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins. Belongs to the G-protein coupled receptor 1 family. Interacts with SKB1. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Receptor, GPCR; Membrane protein, integral; Cell cycle regulation; GPCR, family 1 Chromosomal Location of Human Ortholog: 14q13 Cellular Component: neuron projection; integral to plasma membrane; cytoplasm; plasma membrane Molecular Function:neuropeptide binding; somatostatin receptor activity Biological Process: glutamate signaling pathway; response to starvation; negative regulation of cell proliferation; G-protein signaling, coupled to cyclic nucleotide second messenger; synaptic transmission; cell surface receptor linked signal transduction; cell-cell signaling; neuropeptide signaling pathway; forebrain development; digestion; cerebellum development; spermatogenesis; response to nutrient |
| UniProt Code: | Q02952 |
| NCBI GenInfo Identifier: | 21493022 |
| NCBI Gene ID: | 9590 |
| NCBI Accession: | NP_005091 |
| UniProt Related Accession: | Q02952 |
| Molecular Weight: | 35,345 Da |
| NCBI Full Name: | A-kinase anchor protein 12 isoform 1 |
| NCBI Synonym Full Names: | A kinase (PRKA) anchor protein 12 |
| NCBI Official Symbol: | AKAP12 |
| NCBI Official Synonym Symbols: | SSeCKS; AKAP250 |
| NCBI Protein Information: | A-kinase anchor protein 12; A-kinase anchor protein, 250kDa; AKAP 250; Src-Suppressed C Kinase Substrate; kinase scaffold protein gravin; myasthenia gravis autoantigen gravin |
| UniProt Protein Name: | Somatostatin receptor type 1 |
| UniProt Synonym Protein Names: | SRIF-2 |
| Protein Family: | Somatostatin receptor |
| UniProt Gene Name: | SSTR1 |
| UniProt Entry Name: | SSR1_HUMAN |
