Description
" target="_blank">データシートsystem_update_alt
" target="_blank" >安全性データシート| 抗体名: | ADRB1 Antibody |
| 抗体コード: | PACO00431 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB, IHC, IF |
| 推奨される希釈: | WB:1:500-1:2000, IHC:1:100-1:300, IF:1:200-1:1000 |
| 反応性: | Human, Mouse, Rat |
| 免疫原: | synthesized peptide derived from the Internal region of human AR-Beta1. |
| 憲法: | Liquid |
| ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| 精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
| シノニム: | ADRB1; ADRB1R; B1AR; Beta-1 adrenergic receptor; Beta-1 adrenoreceptor; Beta-1 adrenoceptor |
| UniProt Protein Function: | ADRB1: a GPCR-coupled 7 transmembrane receptor that binds epinephrine and norepinephrine with approximately equal affinity. Mediates the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Interacts with PIST and PSD-95. Localized at the plasma membrane and in the Golgi upon PIST overexpression. Homologous desensitization of the receptor is mediated by its phosphorylation by beta-adrenergic receptor kinase. |
| UniProt Protein Details: | Protein type:Membrane protein, multi-pass; Membrane protein, integral; Receptor, GPCR; GPCR, family 1 Chromosomal Location of Human Ortholog: 10q25.3 Cellular Component: early endosome; integral to plasma membrane; plasma membrane Molecular Function:alpha-2A adrenergic receptor binding; beta-adrenergic receptor activity; beta1-adrenergic receptor activity; epinephrine binding; norepinephrine binding; PDZ domain binding; protein binding; protein heterodimerization activity; Ras guanyl-nucleotide exchange factor activity; receptor signaling protein activity Biological Process: adenylate cyclase activation; brown fat cell differentiation; cell-cell signaling; diet induced thermogenesis; fear response; heat generation; negative regulation of multicellular organism growth; norepinephrine-epinephrine vasodilation involved in regulation of systemic arterial blood pressure; positive regulation of cAMP biosynthetic process; positive regulation of GTPase activity; positive regulation of heart rate by epinephrine-norepinephrine; positive regulation of the force of heart contraction by epinephrine-norepinephrine; response to cold; thermoregulation Disease: Resting Heart Rate, Variation In |
| NCBI Summary: | The adrenergic receptors (subtypes alpha 1, alpha 2, beta 1, and beta 2) are a prototypic family of guanine nucleotide binding regulatory protein-coupled receptors that mediate the physiological effects of the hormone epinephrine and the neurotransmitter norepinephrine. Specific polymorphisms in this gene have been shown to affect the resting heart rate and can be involved in heart failure. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P08588 |
| NCBI GenInfo Identifier: | 48429211 |
| NCBI Gene ID: | 153 |
| NCBI Accession: | P08588.2 |
| UniProt Secondary Accession: | P08588,Q5T5Y4, Q9UKG7, Q9UKG8, B0LPE2, |
| UniProt Related Accession: | P08588 |
| Molecular Weight: | 51,323 Da |
| NCBI Full Name: | Beta-1 adrenergic receptor |
| NCBI Synonym Full Names: | adrenoceptor beta 1 |
| NCBI Official Symbol: | ADRB1 |
| NCBI Official Synonym Symbols: | RHR; B1AR; ADRB1R; BETA1AR |
| NCBI Protein Information: | beta-1 adrenergic receptor |
| UniProt Protein Name: | Beta-1 adrenergic receptor |
| UniProt Synonym Protein Names: | Beta-1 adrenoreceptor; Beta-1 adrenoceptor |
| Protein Family: | Beta-1 adrenergic receptor |
| UniProt Gene Name: | ADRB1 |
| UniProt Entry Name: | ADRB1_HUMAN |
