Description
| 抗体名: | ADH7 Antibody |
| 抗体コード: | PACO00373 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB |
| 推奨される希釈: | WB:1:500-1:2000 |
| 反応性: | Human, Monkey |
| 免疫原: | synthesized peptide derived from the Internal region of human ADH7. |
| 憲法: | Liquid |
| ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| 精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
| シノニム: | ADH7; Alcohol dehydrogenase class 4 mu/sigma chain; Alcohol dehydrogenase class IV mu/sigma chain; Gastric alcohol dehydrogenase; Retinol dehydrogenase |
| UniProt Protein Function: | ADH7: Could function in retinol oxidation for the synthesis of retinoic acid, a hormone important for cellular differentiation. Medium-chain (octanol) and aromatic (m-nitrobenzaldehyde) compounds are the best substrates. Ethanol is not a good substrate but at the high ethanol concentrations reached in the digestive tract, it plays a role in the ethanol oxidation and contributes to the first pass ethanol metabolism. Belongs to the zinc-containing alcohol dehydrogenase family. Class-IV subfamily. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Xenobiotic Metabolism - drug metabolism - cytochrome P450; Xenobiotic Metabolism - metabolism by cytochrome P450; Oxidoreductase; Cofactor and Vitamin Metabolism - retinol; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Amino Acid Metabolism - tyrosine; EC 1.1.1.1; Lipid Metabolism - fatty acid Chromosomal Location of Human Ortholog: 4q23-q24 Cellular Component: cytosol Molecular Function:alcohol dehydrogenase activity; alcohol dehydrogenase activity, zinc-dependent; aldehyde oxidase activity; ethanol binding; receptor antagonist activity; retinol binding; retinol dehydrogenase activity Biological Process: ethanol oxidation; fatty acid omega-oxidation; response to bacterium; response to ethanol; retinoid metabolic process |
| NCBI Summary: | This gene encodes class IV alcohol dehydrogenase 7 mu or sigma subunit, which is a member of the alcohol dehydrogenase family. Members of this family metabolize a wide variety of substrates, including ethanol, retinol, other aliphatic alcohols, hydroxysteroids, and lipid peroxidation products. The enzyme encoded by this gene is inefficient in ethanol oxidation, but is the most active as a retinol dehydrogenase; thus it may participate in the synthesis of retinoic acid, a hormone important for cellular differentiation. The expression of this gene is much more abundant in stomach than liver, thus differing from the other known gene family members. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009] |
| UniProt Code: | P40394 |
| NCBI GenInfo Identifier: | 292495000 |
| NCBI Gene ID: | 131 |
| NCBI Accession: | P40394.2 |
| UniProt Secondary Accession: | P40394,Q13713, A2RRB6, A8MVN9, B2R760, B4DWV6, |
| UniProt Related Accession: | P40394 |
| Molecular Weight: | 42,467 Da |
| NCBI Full Name: | Alcohol dehydrogenase class 4 mu/sigma chain |
| NCBI Synonym Full Names: | alcohol dehydrogenase 7 (class IV), mu or sigma polypeptide |
| NCBI Official Symbol: | ADH7 |
| NCBI Official Synonym Symbols: | ADH4 |
| NCBI Protein Information: | alcohol dehydrogenase class 4 mu/sigma chain |
| UniProt Protein Name: | Alcohol dehydrogenase class 4 mu/sigma chain |
| UniProt Synonym Protein Names: | Alcohol dehydrogenase class IV mu/sigma chain; Gastric alcohol dehydrogenase; Retinol dehydrogenase |
| Protein Family: | Alcohol dehydrogenase |
| UniProt Gene Name: | ADH7 |
| UniProt Entry Name: | ADH7_HUMAN |
