The ADGRA2 Polyclonal Antibody (PACO54554) is a valuable tool for research involving ADGRA2, a G protein-coupled receptor implicated in various physiological processes. This antibody, produced in rabbits, exhibits high reactivity with human samples and has been validated for use in Western blot applications. By binding specifically to the ADGRA2 protein, this antibody enables accurate detection and analysis in a range of cell types, making it well-suited for studies in neuroscience and cardiovascular research.
ADGRA2, also known as GPR124, plays a crucial role in vascular development and blood-brain barrier integrity. Its involvement in angiogenesis and neurogenesis makes it an attractive target for investigating conditions such as neurodegenerative diseases and cardiovascular disorders. Understanding the function of ADGRA2 is essential for advancing our knowledge of these complex processes and developing targeted therapies for related disorders.
Western Blot. Positive WB detected in: A549 whole cell lysate, Rat heart tissue. All lanes: ADGRA2 antibody at 3µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 143, 120, 20 kDa. Observed band size: 143, 120 kDa.
Immunofluorescent analysis of HepG2 cells using PACO54554 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).
Immunohistochemistry of paraffin-embedded human liver cancer using PACO54554 at dilution of 1:100.
Background:
Endothelial receptor which functions as a WNT7-specific coactivator of canonical Wnt signaling (By similarity). Required for normal endothelial cell sprouting and migration in the forebrain and neural tube (By similarity). Has a major role in establishing the blood-brain barrier (By similarity). Binds to the glycosaminoglycans heparin, heparin sulfate, chondroitin sulfate and dermatan sulfate.
GPR124: Endothelial receptor that acts as an essential regulator of CNS angiogenesis. Required for normal endothelial cell sprouting and migration in the forebrain and neural tube. Belongs to the G-protein coupled receptor 2 family. LN-TM7 subfamily. 3 isoforms of the human protein are produced by alternative splicing.Protein type: GPCR, family 2; Receptor, GPCR; Membrane protein, multi-pass; Membrane protein, integralChromosomal Location of Human Ortholog: 8p11.23Cellular Component: cell surface; integral to membrane; plasma membraneMolecular Function: G-protein coupled receptor activityBiological Process: G-protein coupled receptor protein signaling pathway; regulation of chemotaxis; central nervous system development; endothelial cell migration; sprouting angiogenesis; regulation of angiogenesis
