| UniProt Protein Function: | ADAM28: May play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L. May be involved in sperm maturation. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.4.24.-; Membrane protein, integral; Motility/polarity/chemotaxis; Protease Chromosomal Location of Human Ortholog: 8p21.2 Molecular Function:metallopeptidase activity Biological Process: spermatogenesis |
| NCBI Summary: | This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. The protein encoded by this gene is a lymphocyte-expressed ADAM protein. This gene is present in a gene cluster with other members of the ADAM family on chromosome 8. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015] |
| UniProt Code: | Q9UKQ2 |
| NCBI GenInfo Identifier: | 748983380 |
| NCBI Gene ID: | 10863 |
| NCBI Accession: | NP_001291280.1 |
| UniProt Related Accession: | Q9UKQ2 |
| Molecular Weight: | |
| NCBI Full Name: | disintegrin and metalloproteinase domain-containing protein 28 isoform 4 preproprotein |
| NCBI Synonym Full Names: | ADAM metallopeptidase domain 28 |
| NCBI Official Symbol: | ADAM28 |
| NCBI Official Synonym Symbols: | MDCL; MDC-L; eMDCII; ADAM 28; eMDC II |
| NCBI Protein Information: | disintegrin and metalloproteinase domain-containing protein 28 |
| UniProt Protein Name: | Disintegrin and metalloproteinase domain-containing protein 28 |
| UniProt Synonym Protein Names: | Epididymal metalloproteinase-like, disintegrin-like, and cysteine-rich protein II; eMDC II; Metalloproteinase-like, disintegrin-like, and cysteine-rich protein L; MDC-L |
| UniProt Gene Name: | ADAM28 |
