Description
| 抗体名: | ACVR1C Antibody |
| 抗体コード: | PACO03448 |
| サイズ: | 50ug |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, IHC, IF |
| 推奨される希釈: | IHC:1:100-1:300, IF:1:200-1:1000 |
| 反応性: | Human, Mouse, Rat |
| 免疫原: | synthesized peptide derived from the Internal region of human ACTR-IC. |
| 憲法: | Liquid |
| ストレージバッファ: | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
| 精製方法: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
| シノニム: | ACVR1C; ALK7; Activin receptor type-1C; Activin receptor type IC; ACTR-IC; Activin receptor-like kinase 7; ALK-7 |
| UniProt Protein Function: | ALK7: Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. 4 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Kinase, protein; Protein kinase, Ser/Thr (receptor); EC 2.7.11.30; Membrane protein, integral; Protein kinase, TKL; TKL group; STKR family; Type1 subfamily Chromosomal Location of Human Ortholog: 2q24.1 Cellular Component: plasma membrane; activin receptor complex Molecular Function:transforming growth factor beta receptor activity; activin receptor activity, type I; metal ion binding; growth factor binding; ATP binding; receptor signaling protein serine/threonine kinase activity Biological Process: response to dietary excess; sequestering of lipid; apoptotic nuclear changes; response to glucose stimulus; positive regulation of caspase activity; cell differentiation; protein amino acid phosphorylation; negative regulation of insulin secretion; response to insulin stimulus |
| NCBI Summary: | ACVR1C is a type I receptor for the TGFB (see MIM 190180) family of signaling molecules. Upon ligand binding, type I receptors phosphorylate cytoplasmic SMAD transcription factors, which then translocate to the nucleus and interact directly with DNA or in complex with other transcription factors (Bondestam et al., 2001 [PubMed 12063393]).[supplied by OMIM, Mar 2008] |
| UniProt Code: | Q8NER5 |
| NCBI GenInfo Identifier: | 74762565 |
| NCBI Gene ID: | 130399 |
| NCBI Accession: | Q8NER5.1 |
| UniProt Secondary Accession: | Q8NER5,Q4ZFZ8, Q86UL1, Q86UL2, Q8TBG2, |
| UniProt Related Accession: | Q8NER5 |
| Molecular Weight: | Calculated MW: 37kDa/46kDa/49kDa/54kDaObserved MW: 60kDa |
| NCBI Full Name: | Activin receptor type-1C |
| NCBI Synonym Full Names: | activin A receptor, type IC |
| NCBI Official Symbol: | ACVR1C |
| NCBI Official Synonym Symbols: | ALK7; ACVRLK7 |
| NCBI Protein Information: | activin receptor type-1C; ALK-7; ACVR1C; ACTR-IC; activin receptor type IC; activin receptor-like kinase 7 |
| UniProt Protein Name: | Activin receptor type-1C |
| UniProt Synonym Protein Names: | Activin receptor type IC; ACTR-IC; Activin receptor-like kinase 7; ALK-7 |
| Protein Family: | Activin receptor |
| UniProt Gene Name: | ACVR1C |
| UniProt Entry Name: | ACV1C_HUMAN |
