Description
| 抗体名: | ACVR1 Antibody (PACO44129) |
| 抗体コード: | PACO44129 |
| サイズ: | 50ul |
| 宿主種: | Rabbit |
| 申し込み: | ELISA, WB, IHC, IF |
| 推奨される希釈: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IHC:1:20-1:200, IF:1:50-1:200 |
| 反応性: | Human, Mouse |
| 免疫原: | Recombinant Human Activin receptor type-1 protein (20-125AA) |
| 憲法: | Liquid |
| ストレージバッファ: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| 精製方法: | Antigen Affinity Purified |
| 抗体のクローン性: | Polyclonal |
| アイソタイプ: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot. All lanes: ACVR1 antibody at 6µg/ml. Lane 1: A549 whole cell lysate. Lane 2: HepG2 whole cell lysate. Lane 3: Mouse gonad tissue. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 39 kDa. Observed band size: 39 kDa.. |
 | Immunofluorescent analysis of PC-3 cells using PACO44129 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
 | Immunohistochemistry of paraffin-embedded human kidney tissue using PACO44129 at dilution of 1:100. |
| バックグラウンド: | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis. |
| シノニム: | Activin receptor type-1 (EC 2.7.11.30) (Activin receptor type I) (ACTR-I) (Activin receptor-like kinase 2) (ALK-2) (Serine/threonine-protein kinase receptor R1) (SKR1) (TGF-B superfamily receptor type I) (TSR-I), ACVR1, ACVRLK2 |
| UniProt Protein Function: | ALK2: On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin. May be involved for left-right pattern formation during embryogenesis. Interacts with FKBP1A. Interacts with FCHO1. Expressed in normal parenchymal cells, endothelial cells, fibroblasts and tumor-derived epithelial cells. Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. |
| UniProt Protein Details: | Protein type:Membrane protein, integral; Kinase, protein; Protein kinase, TKL; EC 2.7.11.30; Protein kinase, Ser/Thr (receptor); TKL group; STKR family; Type1 subfamily Chromosomal Location of Human Ortholog: 2q23-q24 Cellular Component: activin receptor complex; integral to plasma membrane Molecular Function:activin binding; activin receptor activity, type I; ATP binding; protein binding; protein homodimerization activity; protein kinase activity; protein serine/threonine kinase activity; SMAD binding; transforming growth factor beta binding Biological Process: activin receptor signaling pathway; BMP signaling pathway; G1/S transition of mitotic cell cycle; negative regulation of activin receptor signaling pathway; negative regulation of signal transduction; peptidyl-threonine phosphorylation; positive regulation of bone mineralization; positive regulation of cell migration; positive regulation of osteoblast differentiation; positive regulation of transcription from RNA polymerase II promoter; positive regulation of transcription, DNA-dependent; protein amino acid phosphorylation; regulation of ossification; transforming growth factor beta receptor signaling pathway Disease: Fibrodysplasia Ossificans Progressiva |
| NCBI Summary: | Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structurally related signaling proteins. Activins signal through a heteromeric complex of receptor serine kinases which include at least two type I ( I and IB) and two type II (II and IIB) receptors. These receptors are all transmembrane proteins, composed of a ligand-binding extracellular domain with cysteine-rich region, a transmembrane domain, and a cytoplasmic domain with predicted serine/threonine specificity. Type I receptors are essential for signaling; and type II receptors are required for binding ligands and for expression of type I receptors. Type I and II receptors form a stable complex after ligand binding, resulting in phosphorylation of type I receptors by type II receptors. This gene encodes activin A type I receptor which signals a particular transcriptional response in concert with activin type II receptors. Mutations in this gene are associated with fibrodysplasia ossificans progressive. [provided by RefSeq, Jul 2008] |
| UniProt Code: | Q04771 |
| NCBI GenInfo Identifier: | 462447 |
| NCBI Gene ID: | 90 |
| NCBI Accession: | Q04771.1 |
| UniProt Related Accession: | Q04771 |
| Molecular Weight: | 57,153 Da |
| NCBI Full Name: | Activin receptor type-1 |
| NCBI Synonym Full Names: | activin A receptor type 1 |
| NCBI Official Symbol: | ACVR1 |
| NCBI Official Synonym Symbols: | FOP; ALK2; SKR1; TSRI; ACTRI; ACVR1A; ACVRLK2 |
| NCBI Protein Information: | activin receptor type-1 |
| UniProt Protein Name: | Activin receptor type-1 |
| UniProt Synonym Protein Names: | Activin receptor type I; ACTR-I; Activin receptor-like kinase 2; ALK-2; Serine/threonine-protein kinase receptor R1; SKR1; TGF-B superfamily receptor type I; TSR-I |
| Protein Family: | Activin receptor |
| UniProt Gene Name: | ACVR1 |
| UniProt Entry Name: | ACVR1_HUMAN |
| Antibodies |
| Anti-ACVR1 Antibody (CAB7542) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
